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Towards Preparative Chemoenzymatic Oxidative Decarboxylation of Glutamic Acid

Journal Article (2020)
Author(s)

X. Xu (TU Delft - BT/Biocatalysis)

Andrada But (TU Delft - BT/Biocatalysis)

Ron Wever (Universiteit van Amsterdam)

F Hollmann (TU Delft - BT/Biocatalysis)

Research Group
BT/Biocatalysis
Copyright
© 2020 X. Xu, A. But, Ron Wever, F. Hollmann
DOI related publication
https://doi.org/10.1002/cctc.201902194
More Info
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Publication Year
2020
Language
English
Copyright
© 2020 X. Xu, A. But, Ron Wever, F. Hollmann
Related content
Research Group
BT/Biocatalysis
Issue number
8
Volume number
12
Pages (from-to)
2180-2183
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Abstract

The chemoenzymatic oxidative decarboxylation of glutamic acid to the corresponding nitrile using the vanadium chloroperoxidase from Curvularia inaequalis (CiVCPO) as HOBr generation catalysts has been investigated. Product inhibition was identified as major limitation. Nevertheless, 1630000 turnovers and kcat of 75 s−1 were achieved using 100 mM glutamate. The semi-preparative enzymatic oxidative decarboxylation of glutamate was also demonstrated.

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