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Miniaturization of Process Analytical Technology: from Concept to Reality

Doctoral Thesis (2023)
Author(s)

M. Neves Sao Pedro (TU Delft - Applied Sciences)

Contributor(s)

M. Ottens – Promotor (TU Delft - Applied Sciences)

M. Eppink – Promotor (Byondis B.V., Nijmegen, Wageningen University & Research)

Research Group
BT/Bioprocess Engineering
DOI related publication
https://doi.org/10.4233/uuid:ec3f81c3-1bb4-4724-9f97-fff46e3c1c66 Final published version
More Info
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Publication Year
2023
Language
English
Related content
Research Group
BT/Bioprocess Engineering
ISBN (print)
978-94-6384-473-4
Downloads counter
334
Collections
Institutional Repository
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Abstract

Continuous biomanufacturing is considered the future phase for the optimization of production processes in the biopharmaceutical industry. Productivity, product quality and consistency are greatly improved while production costs and environmental footprint are drastically reduced. The manufacturing of monoclonal antibodies (mAbs), an important biopharmaceutical in the treatment of cancers, autoimmune disorders, and, more recently, COVID-19, is eligible for this continuous processing due to patent expiration and the subsequent need to lower manufacturing costs...