Miniaturization of Process Analytical Technology: from Concept to Reality

Doctoral thesis (2023)

Authors

M. Neves Sao Pedro BT/Bioprocess Engineering - AS
Research Group
BT/Bioprocess Engineering (AS) (TU Delft)
Copyright: © 2023 M. Neves Sao Pedro
DOI
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https://doi.org/10.4233/uuid:ec3f81c3-1bb4-4724-9f97-fff46e3c1c66
Antibody aggregation Continuous Biomanufacturing Process Analytical Technology (PAT) Microfluidic Sensor Fluorescent Dyes
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Published Date

2023

Language

English

Faculty

Applied Sciences

Department

BT/Biotechnologie

Research Group

BT/Bioprocess Engineering

Abstract

Continuous biomanufacturing is considered the future phase for the optimization of production processes in the biopharmaceutical industry. Productivity, product quality and consistency are greatly improved while production costs and environmental footprint are drastically reduced. The manufacturing of monoclonal antibodies (mAbs), an important biopharmaceutical in the treatment of cancers, autoimmune disorders, and, more recently, COVID-19, is eligible for this continuous processing due to patent expiration and the subsequent need to lower manufacturing costs...