Engineering ketoreductases for the enantioselective synthesis of chiral alcohols
Li Qiao (Hangzhou Normal University)
Zhiyuan Luo (Hangzhou Normal University)
Haomin Chen (Hangzhou Normal University)
Pengfei Zhang (Hangzhou Normal University)
Anming Wang (Hangzhou Normal University)
R.A. Sheldon (TU Delft - BT/Biocatalysis, University of Witwatersrand)
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Abstract
The use of engineered ketoreductases (KREDS), both as whole microbial cells and isolated enzymes, in the highly enantiospecific reduction of prochiral ketones is reviewed. The homochiral alcohol products are key intermediates in, for example, pharmaceuticals synthesis. The application of sophisticated protein engineering and enzyme immobilisation techniques to increase industrial viability are discussed.
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