Interfacial Microcompartmentalization by Kinetic Control of Selective Interfacial Accumulation

Journal Article (2020)
Author(s)

Q. Liu (TU Delft - ChemE/Product and Process Engineering)

Zhenyu Yuan (East China University of Science and Technology)

Meng Zhao (TU Delft - (OLD) MSE-1)

M.A.N. Huisman

Gido Drewes (Student TU Delft)

T.K. Piskorz (TU Delft - ChemE/Advanced Soft Matter)

Serhii Mytnyk (TU Delft - ChemE/Product and Process Engineering)

Ger J.M. Koper (TU Delft - ChemE/Advanced Soft Matter)

E. Mendes (TU Delft - ChemE/Advanced Soft Matter)

Jan H. Van Esch (TU Delft - ChemE/Advanced Soft Matter)

Research Group
ChemE/Product and Process Engineering
DOI related publication
https://doi.org/10.1002/anie.202009701
More Info
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Publication Year
2020
Language
English
Research Group
ChemE/Product and Process Engineering
Issue number
52
Volume number
59
Pages (from-to)
23748-23754

Abstract

Reported here is a 2D, interfacial microcompartmentalization strategy governed by 3D phase separation. In aqueous polyethylene glycol (PEG) solutions doped with biotinylated polymers, the polymers spontaneously accumulate in the interfacial layer between the oil-surfactant-water interface and the adjacent polymer phase. In aqueous two-phase systems, these polymers first accumulated in the interfacial layer separating two polymer solutions and then selectively migrated to the oil-PEG interfacial layer. By using polymers with varying photopolymerizable groups and crosslinking rates, kinetic control and capture of spatial organisation in a variety of compartmentalized macroscopic structures, without the need of creating barrier layers, was achieved. This selective interfacial accumulation provides an extension of 3D phase separation towards synthetic compartmentalization, and is also relevant for understanding intracellular organisation.

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