Uncompromised ten-year survival of oldest old carrying somatic mutations in DNMT3A and TET2

Poster (2016)

Authors

E.B. van den Akker Pattern Recognition and Bioinformatics - EEMCS , Leiden University Medical Center
Steven J. Pitts Rinat-Pfizer Inc.
M. Beekman Leiden University Medical Center, Erasmus MC
M.J.T. Reinders Pattern Recognition and Bioinformatics - EEMCS
PE Slagboom Erasmus MC, Leiden University Medical Center
Research Group
Pattern Recognition and Bioinformatics (EEMCS) (TU Delft)
More Info
expand_more

Published Date

17-03-2016

Language

English

Reuse Rights

Other than for strictly personal use, it is not permitted to download, forward or distribute the text or part of it, without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license such as Creative Commons.

Faculty

Electrical Engineering, Mathematics and Computer Science

Department

Intelligent Systems

Research Group

Pattern Recognition and Bioinformatics

Abstract

Recent large-scale sequencing studies report recurrent somatic mutations in the blood of elderly individuals in genes previously linked to clonal expansion of hematopoietic stem cells [1-4]. Particularly for DNMT3A and TET2, a steep ageassociated increase in the prevalence of somatic mutations is observed from middle age onward [2-4]. In addition, prospective analyses performed in predominantly middle-aged individuals show an increased risk for all-cause mortality for carriers of such mutations as compared with non-carriers [3,4]. Jointly, these data suggest a rapidly increasing vulnerability among the elderly for adverse health effects associated with clonal expansion of hematopoietic stem cells.