Photocatalysis to promote cell-free biocatalytic reactions
Georg Höfler (TU Delft - BT/Biocatalysis)
F Hollmann (TU Delft - BT/Biocatalysis)
C.E. Paul (TU Delft - BT/Biocatalysis)
M.C.R. Rauch (TU Delft - BT/Biocatalysis)
M.M.C.H. van Schie (TU Delft - BT/Biocatalysis)
Sébastien Willot (TU Delft - BT/Biocatalysis)
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Abstract
Cofactors assist enzymes to catalyze reactions and are indispensable and ubiquitous in nature, playing a central role in metabolic pathways. In biocatalysis, common redox cofactors such as nicotinamide, flavin and heme can be activated by light or synthetized to vary redox potentials, leading to different types of reactions for the formation of interesting chiral products, unattainable through classical chemical methods. This chapter will focus on light-driven cell-free biocatalytic reactions activated via their redox cofactors.