Print Email Facebook Twitter Preoperative assessment of the histopathological growth patterns of colorectal liver metastasis on CT using artificial intelligence Title Preoperative assessment of the histopathological growth patterns of colorectal liver metastasis on CT using artificial intelligence Author van Gurp, Samuel (TU Delft Mechanical, Maritime and Materials Engineering) Contributor Starmans, Martijn (mentor) Voigt, Kelly (graduation committee) Klein, Stefan (graduation committee) Vos, F.M. (mentor) Degree granting institution Delft University of Technology Programme Biomedical Engineering | Medical Physics Date 2023-07-31 Abstract Background: Histopathological growth patterns (HGP) are a biomarker for predicting survival and systemic treatment effectiveness in colorectal liver metastasis (CRLM). Currently, HGP assessment in CRLM requires the resection specimen. Predicting the HGP from preoperative medical imaging could allow more personalised care and better outcomes. Methods: 252 patients underwent CRLM resection between 2004 and 2018 without receiving any systemic treatment. Patients were characterised as having either pure desmoplastic growth (dHGP) or any other type of growth pattern combination (non-dHGP) (21% dHGP; 79% non-dHGP). These categories were chosen because pure desmoplastic growth is predictive of better overall survival. regions of interest were automatically extracted using a UNet based segmentation model. These ROIs were passed to a radiomics model and a deep learning model to classify between dHGP/non-dHGP and predict the fraction of dHGP. Results: The best-performing classification method was the radiomic approach achieving an AUC of 0.67 (95% CI: 0.58-0.78), whereas the best-performance deep learning model achieved an average AUC value of 0.59 (95% CI: 0.53-0.65). Additionally, regression predicting the fraction of dHGP failed, with the predicted values showing no significant correlation with the actual value. Conclusions: Radiomics can be used to assess HGP, however further improvements in predictive performance are needed before these methods can be applied. Subject Colorectal Liver MetastasesHistopathological Growth PatternCT scanMachine LearningDeep LearningRadiomics To reference this document use: http://resolver.tudelft.nl/uuid:13733886-4d6f-4d5b-bfe3-9cde77614f38 Part of collection Student theses Document type master thesis Rights © 2023 Samuel van Gurp Files PDF Samuel_Thesis_final_1_.pdf 1.66 MB Close viewer /islandora/object/uuid:13733886-4d6f-4d5b-bfe3-9cde77614f38/datastream/OBJ/view