Print Email Facebook Twitter Photo cleavable thioacetal block copolymers for controlled release Title Photo cleavable thioacetal block copolymers for controlled release Author Men, Y. (TU Delft ChemE/Advanced Soft Matter) Breve, T. (TU Delft ChemE/Advanced Soft Matter) Liu, H. (TU Delft RST/Applied Radiation & Isotopes) Denkova, A.G. (TU Delft RST/Applied Radiation & Isotopes) Eelkema, R. (TU Delft ChemE/Advanced Soft Matter) Date 2021 Abstract We present a new light cleavable polymer containing o-nitrobenzene thioacetal groups in the main chain. By conjugation to a PEG block, we synthesized block copolymers capable of forming nanoparticles in aqueous solution. We studied drug encapsulation and release using the model drug Nile Red. Irradiation with UV-A light (365 nm) leads to efficient degradation of the polymers and associated burst release of the payload. Unlike other thioacetal and thioketal polymers, these polymers are stable to reactive oxygen species (ROS), preventing non-triggered release. Moreover, the nanocarriers showed low cytotoxicity in cell viability experiments. To reference this document use: http://resolver.tudelft.nl/uuid:22237b17-da74-4abe-a858-80e611a4b294 DOI https://doi.org/10.1039/d1py00514f ISSN 1759-9954 Source Polymer Chemistry, 12 (25), 3612-3618 Part of collection Institutional Repository Document type journal article Rights © 2021 Y. Men, T. Breve, H. Liu, A.G. Denkova, R. Eelkema Files PDF d1py00514f.pdf 1.86 MB Close viewer /islandora/object/uuid:22237b17-da74-4abe-a858-80e611a4b294/datastream/OBJ/view