Print Email Facebook Twitter Nocebo hyperalgesia and other expectancy-related factors in daily fibromyalgia pain Title Nocebo hyperalgesia and other expectancy-related factors in daily fibromyalgia pain: Combining experimental and electronic diary methods Author Karacaoglu, Merve (Universiteit Leiden) Peerdeman, Kaya J. (Universiteit Leiden) Karch, Julian D. (Universiteit Leiden) van Middendorp, Henriët (Universiteit Leiden) Evers, A.W.M. (TU Delft Applied Ergonomics and Design; Universiteit Leiden; Leiden University Medical Center; Erasmus Universiteit Rotterdam) Date 2024 Abstract Objective: Expectancies are known to shape pain experiences, but it remains unclear how different types of expectancies contribute to daily pain fluctuations in fibromyalgia. This combined experimental and diary study aims to provide insights into how experimentally-derived nocebo hyperalgesia and other, diary-derived, expectancy-related factors are associated with each other and with daily pain in fibromyalgia. Methods: Forty-one female patients with fibromyalgia first participated in a lab procedure measuring nocebo hyperalgesia magnitude, then filled out an electronic diary 3 times a day over 3 weeks regarding the expectancy-related factors of pain expectancy, anxiety, optimism, and pain-catastrophizing thoughts, and current pain intensity. Results: Our results indicate that experimentally-induced nocebo hyperalgesia was not significantly related to diary-assessed expectancy-related factors and did not predict daily fibromyalgia pain. Higher levels of the self-reported expectancy-related factors pain expectancy and pain catastrophizing, but not anxiety and optimism, predicted moment-to-moment pain increases in fibromyalgia, after controlling for current pain, moment-of-day and all other expectancy-related factors. Conclusion: Our exploratory research findings indicate that self-reported expectancy-related factors, particularly pain expectancy and pain catastrophizing, are potentially more relevant for predicting daily pain experience than experimentally-induced nocebo hyperalgesia. Further translation of nocebo hyperalgesia is needed from experimental to Ecological Momentary Assessment research. Our findings imply that targeting the decrease in pain expectancy and catastrophizing thoughts e.g., via Cognitive Behavioral Therapy, have potential for improving daily pain levels in fibromyalgia. Subject Diary studyExpectancyFibromyalgiaNocebo hyperalgesiaPain To reference this document use: http://resolver.tudelft.nl/uuid:2890d82d-dfe0-487c-af85-0c101d04de93 DOI https://doi.org/10.1016/j.jpsychores.2024.111676 ISSN 0022-3999 Source Journal of Psychosomatic Research, 182 Part of collection Institutional Repository Document type journal article Rights © 2024 Merve Karacaoglu, Kaya J. Peerdeman, Julian D. Karch, Henriët van Middendorp, A.W.M. Evers Files PDF 1-s2.0-S0022399924000886-main.pdf 491.8 KB Close viewer /islandora/object/uuid:2890d82d-dfe0-487c-af85-0c101d04de93/datastream/OBJ/view