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From Pain to Brain: Exploring Functional Connectivity in Chronic Pain Patients with Magnetoencephalography

de Moel, Lisanne (author)

Introduction:<br/>Chronic Pain (CP) presents a complex and prevalent issue that significantly affects individuals and society. Exploring the complexities of CP involves analyzing Functional Connectivity (FC), a process that identifies how different brain regions communicate across distances. Magnetoencephalography (MEG) is particularly effective...

master thesis 2024

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Nocebo hyperalgesia and other expectancy-related factors in daily fibromyalgia pain: Combining experimental and electronic diary methods

Karacaoglu, Merve (author), Peerdeman, Kaya J. (author), Karch, Julian D. (author), van Middendorp, Henriët (author), Evers, A.W.M. (author)

Objective: Expectancies are known to shape pain experiences, but it remains unclear how different types of expectancies contribute to daily pain fluctuations in fibromyalgia. This combined experimental and diary study aims to provide insights into how experimentally-derived nocebo hyperalgesia and other, diary-derived, expectancy-related...

journal article 2024

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Time-action and patient experience analyses of locally advanced cervical cancer brachytherapy

Perez, S.M. (author), van Paassen, Rosemarijn (author), Wauben, L.S.G.L. (author), Straathof, R. (author), van de Berg, N.J. (author), Dankelman, J. (author), Heijmen, Ben J.M. (author), Kolkman–Deurloo, Inger–Karine K. (author), Nout, Remi A. (author)

BACKGROUND AND PURPOSE: Although MRI-based image guided adaptive brachytherapy (IGABT) for locally advanced cervical cancer (LACC) has resulted in favorable outcomes, it can be logistically complex and time consuming compared to 2D image-based brachytherapy, and both physically and emotionally intensive for patients. This prospective study...

journal article 2024

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Magnetoencephalography to image the influence of different spinal cord stimulation paradigms on somatosensory evoked responses

Luijten, Janne (author)

<b>Introduction</b><br/>Chronic pain is an increasing problem in terms of prevalence and disease-related costs. Due to its complexity, it is difficult to treat. Spinal cord stimulation (SCS) is a neurostimulation therapy with a relatively good success rate for patients with severe, intractable chronic pain. The mechanisms of action (MOAs) of SCS...

master thesis 2023

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A Study Into The Effects Of Using Pain/Gain Sharing Mechanisms To Improve The Contract Management In The Supply Chain: Designing A Strategic Framework To Implement Pain/Gain Sharing Mechanisms

Al Saadi, Aia (author)

The Dutch construction industry faces the recurring issues related to delays and conflicts, resulting in adverse effects on construction projects. Researchers have proposed pain/gain sharing mechanisms as a potential solution to address these issues. However, there is a gap between theoretical suggestions and practical implementation. This...

master thesis 2023

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Learned Nocebo Effects on Cutaneous Sensations of Pain and Itch: A Systematic Review and Meta-analysis of Experimental Behavioral Studies on Healthy Humans

Thomaidou, Mia A. (author), Blythe, Joseph S. (author), Peerdeman, Kaya J. (author), Van Laarhoven, Antoinette I.M. (author), Van Schothorst, Myrthe M.E. (author), Veldhuijzen, Dieuwke S. (author), Evers, A.W.M. (author)

Objective In past decades, the field of nocebo research has focused on studying how sensory perception can be shaped by learning. Nocebo effects refer to aggravated sensory experiences or increased sensitivity to sensations such as pain and itch resulting from treatment-related negative experiences. Behavioral conditioning and verbal...

journal article 2023

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Susceptibility to Nocebo Hyperalgesia, Dispositional Optimism, and Trait Anxiety as Predictors of Nocebo Hyperalgesia Reduction

Karacaoglu, Merve (author), Meijer, Simone (author), Peerdeman, Kaya J. (author), Dusseldorp, Elise (author), Jensen, Karin B. (author), Veldhuijzen, Dieuwke S. (author), van Middendorp, Henriët (author), Evers, A.W.M. (author)

OBJECTIVES: The current paper explores the psychological predictors of nocebo hyperalgesia and whether the reduction of nocebo hyperalgesia can be predicted by susceptibility to nocebo hyperalgesia and psychological characteristics. METHODS: Nocebo effects on pressure pain were first experimentally induced in 83 healthy female participants...

journal article 2023

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Nocebo Hyperalgesia in Patients With Fibromyalgia and Healthy Controls: An Experimental Investigation of Conditioning and Extinction Processes at Baseline and 1-Month Follow-up

Karacaoglu, Merve (author), Peerdeman, Kaya J. (author), Numans, M.E. (author), Stolk, Martha R. (author), Meijer, Simone (author), Klinger, Regine (author), Veldhuijzen, Dieuwke S. (author), van Middendorp, Henriët (author), Evers, A.W.M. (author)

Nocebo effects are adverse treatment outcomes that are not ascribed to active treatment components. Potentially, their magnitude might be higher in patients with chronic pain compared to healthy controls since patients likely experience treatment failure more frequently. The current study investigated group differences in the induction and...

journal article 2023

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Design of Child-robot Interactions for Comfort and Distraction from Post-operative Pain and Distress

Ferrari, Oriana Isabella (author), Zhang, Feiran (author), Braam, Ayrton A. (author), Van Gurp, Jules A.M. (author), Broz, F. (author), Barakova, Emilia I. (author)

There are numerous strategies for reducing the stress and anxiety associated with pain that children experience before and after surgery. There is a potential communication barrier between hospital staff and the child which may result in inadequate pain management. Social robots may reduce the gap between the support that personnel can...

conference paper 2023

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Magnetoencephalography to characterize cortical effects of conditioned pain modulation in patients treated with spinal cord stimulation

Reinders, Laurien (author)

<b>Introduction</b>: Spinal Cord Stimulation (SCS) is a successful last-resort treatment for chronic pain patients, although its exact mechanisms of action (MOAs) still need to be unraveled. The MOAs of SCS partly rely on spinal mechanisms (gate control theory) and supraspinal mechanisms likely play a role as well. Pain processing involves a...

master thesis 2022

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QUANTIFYING EFFECTS OF SPINAL CORD STIMULATION IN CHRONIC REGIONAL PAIN SYNDROME PATIENTS

van Lange, Eline (author)

Background: Complex regional pain syndrome (CRPS) is a clinical disorder characterized by continuous, disproportionate pain and sensory, vasomotor, sudomotor and motor trophic changes. CRPS patients have a heterogeneous clinical picture caused by multiple underlying pathophysiology mechanisms including inflammation, vasomotor disturbances and...

master thesis 2022

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Placebo effects on cutaneous pain and itch: a systematic review and meta-analysis of experimental results and methodology

Blythe, Joseph S. (author), Thomaidou, Mia A. (author), Peerdeman, Kaya J. (author), van Laarhoven, Antoinette I.M. (author), van Schothorst, Myrthe M.E. (author), Veldhuijzen, Dieuwke S. (author), Evers, A.W.M. (author)

Placebo effects, positive treatment outcomes that go beyond treatment processes, can alter sensations through learning mechanisms. Understanding how methodological factors contribute to the magnitude of placebo effects will help define the mechanisms by which these effects occur. We conducted a systematic review and meta-analysis of experimental...

journal article 2022

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Understanding Design Preferences for Robots for Pain Management: A Co-Design Study

Zhang, Feiran (author), Broz, F. (author), Dertien, Edwin (author), Kousi, Nefeli (author), Van Gurp, Jules A.M. (author), Ferrari, Oriana Isabella (author), Malagon, Ignacio (author), Barakova, Emilia I. (author)

There is growing interest in psychological interventions using socially assistive robots to mitigate distress and pain in the pediatric population. This work seeks to address the deficit in understanding of what features and functionality young children and their parents desire to help with pain management by using co-design, a common...

conference paper 2022

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Do individual psychological characteristics predict induction and generalization of nocebo and placebo effects on pain and itch?

Weng, Lingling (author), van Laarhoven, Antoinette I.M. (author), Peerdeman, Kaya J. (author), Evers, A.W.M. (author)

Background: Nocebo and placebo effects, i.e., adverse or beneficial treatment effects, respectively, putatively due to expectancies can modulate pain and itch. These effects can generalize within the pain or itch modality. Predicting the induction and generalization of these effects can be helpful in clinical practice. This study aims to...

journal article 2022

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Game mechanics in eHealth interventions promoting self-management in young people with chronic diseases: a protocol for a systematic review and meta-analyses from the eHealth Junior Consortium

Estévez-López, Fernando (author), Levelt, Lisa (author), van 't Veer, Job (author), Hrehovcsik, Micah M. (author), Visch, V.T. (author), Bramer, Wichor M. (author), Hillegers, Manon H.J. (author), van de Putte, Elise (author), Veltkamp, Remco C. (author)

INTRODUCTION: Young people (aged 10-25 years) with chronic diseases are vulnerable to have reduced social participation and quality of life. It is important to empower young people to engage in their chronic diseases self-management. In comparison with traditional face-to-face care, interventions delivered through the internet and related...

journal article 2022

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Mitigating Neuropathic Pain: From Theory to Practice: Inhibiting Neuroma Pain In­-silico and Measuring Neural Activity In­-vivo

Verzijl, Hubald (author)

<i>Neuropathic pain</i> (NP) affects approximately seven to ten percent of the general population. Seventeen percent of NP patients scored their life as “worse than death”. A myriad of causes may underlie NP, such as stroke or spinal cord injury. Also, damage or disease of the <i>peripheral nervous system</i> (PNS) may result in NP. One of the...

master thesis 2021

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Magnetoencephalography to Image the Acute Modulation of Brain Activity by Spinal Cord Stimulation Treatment in Chronic Pain Patients

Ottenheym, Lucas (author)

Background: Spinal cord stimulation (SCS) is a last resort therapy for chronic pain syndromes, of which the exact mechanisms of action remain unknown. Although often effective, not all patients have sufficient pain reduction after implantation. Objective: Analyse the acute effects of tonic and burst SCS on spectral features in the whole brain...

master thesis 2021

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Collaboration through gain-and-pain-share mechanism: A roadmap to incentivize collaboration by gain-and-pain-sharing concepts

Ooms, Rob (author)

This research aims to identify gain-and-pain-sharing methods to foster a collaborative environment to create win-win situations and create mutual objectives. To do so, gain-and-pain-sharing methods that can positively influence a collaborative environment are explored. This study is restricted to the Dutch construction sector because it is for...

master thesis 2021

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How Negative Experience Influences the Brain: A Comprehensive Review of the Neurobiological Underpinnings of Nocebo Hyperalgesia

Thomaidou, Mia A. (author), Peerdeman, Kaya J. (author), Koppeschaar, Melissa I. (author), Evers, A.W.M. (author), Veldhuijzen, Dieuwke S. (author)

This comprehensive review summarizes and interprets the neurobiological correlates of nocebo hyperalgesia in healthy humans. Nocebo hyperalgesia refers to increased pain sensitivity resulting from negative experiences and is thought to be an important variable influencing the experience of pain in healthy and patient populations. The young...

review 2021

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Online recognition of oral activities

Vijayaragavan, Jaya Rupini (author)

Temporomandibular disorders (TMD) affect about 5-12 percentage of individuals with consequences such as jaw noises, clicking, myofascial pain, discomfort, limited mandibular range of motion and stress. Treatments depend on the cause and extent of the damage and part of the joint or jaw affected. When exact aetiology of TMD is unclear, generic...

master thesis 2020