Print Email Facebook Twitter Laser-driven resonance of dye-doped oil-coated microbubbles Title Laser-driven resonance of dye-doped oil-coated microbubbles: Experimental study Author Lajoinie, Guillaume (University of Twente) Lee, Jeong Yu (University of Oxford) Owen, Joshua (University of Oxford) Kruizinga, P. (TU Delft ImPhys/Acoustical Wavefield Imaging; Erasmus MC) de Jong, N. (TU Delft ImPhys/Acoustical Wavefield Imaging; Erasmus MC) Van Soest, Gijs (Erasmus MC) Stride, Eleanor (University of Oxford) Versluis, Michel (University of Twente) Date 2017 Abstract Photoacoustic (PA) imaging offers several attractive features as a biomedical imaging modality, including excellent spatial resolution and functional information such as tissue oxygenation. A key limitation, however, is the contrast to noise ratio that can be obtained from tissue depths greater than 1-2 mm. Microbubbles coated with an optically absorbing shell have been proposed as a possible contrast agent for PA imaging, offering greater signal amplification and improved biocompatibility compared to metallic nanoparticles. A theoretical description of the dynamics of a coated microbubble subject to laser irradiation has been developed previously. The aim of this study was to test the predictions of the model. Two different types of oil-coated microbubbles were fabricated and then exposed to both pulsed and continuous wave (CW) laser irradiation. Their response was characterized using ultra high-speed imaging. Although there was considerable variability across the population, good agreement was found between the experimental results and theoretical predictions in terms of the frequency and amplitude of microbubble oscillation following pulsed excitation. Under CW irradiation, highly nonlinear behavior was observed which may be of considerable interest for developing different PA imaging techniques with greatly improved contrast enhancement. Subject LasersMicrobubblesAcoustic signal processingMedical imagingAcoustic transducers To reference this document use: http://resolver.tudelft.nl/uuid:3d2f11ed-294e-40d9-9ed6-a102967dd402 DOI https://doi.org/10.1121/1.4985560 ISSN 0001-4966 Source The Journal of the Acoustical Society of America, 141 (6), 4832-4846 Part of collection Institutional Repository Document type journal article Rights © 2017 Guillaume Lajoinie, Jeong Yu Lee, Joshua Owen, P. Kruizinga, N. de Jong, Gijs Van Soest, Eleanor Stride, Michel Versluis Files PDF 1.4985560_1.pdf 3.64 MB Close viewer /islandora/object/uuid:3d2f11ed-294e-40d9-9ed6-a102967dd402/datastream/OBJ/view