Title
Saturation-pulse prepared heart-rate independent inversion-recovery (SAPPHIRE) biventricular T1 mapping: inter-field strength, head-to-head comparison of diastolic, systolic and dark-blood measurements
Author
Alfarih, Mashael (University College London; Imam Abdulrahman Bin Faisal university; St Bartholomew’s Hospital, London)
Augusto, João B. (University College London; St Bartholomew’s Hospital, London)
Knott, Kristopher D. (University College London)
Fatih, Nasri (University College London)
Kumar, M. Praveen (Post Graduate Institute of Medical Education and Research, Chandigarh)
Boubertakh, Redha (Queen Mary University of London)
Hughes, Alun D. (University College London; UCL MRC Unit for Lifelong Health and Ageing, London)
Moon, James C. (University College London; St Bartholomew’s Hospital, London)
Weingärtner, S.D. (TU Delft ImPhys/Computational Imaging; TU Delft ImPhys/Medical Imaging; University of Minnesota Twin Cities) 
Captur, Gabriella (University College London; St Bartholomew’s Hospital, London; UCL MRC Unit for Lifelong Health and Ageing, London; Royal Free Hospital NHS Trust, London)
Date
2022
Abstract
Background: To assess the feasibility of biventricular SAPPHIRE T1 mapping in vivo across field strengths using diastolic, systolic and dark-blood (DB) approaches. Methods: 10 healthy volunteers underwent same-day non-contrast cardiovascular magnetic resonance at 1.5 Tesla (T) and 3 T. Left and right ventricular (LV, RV) T1 mapping was performed in the basal, mid and apical short axis using 4-variants of SAPPHIRE: diastolic, systolic, 0th and 2nd order motion-sensitized DB and conventional modified Look-Locker inversion recovery (MOLLI). Results: LV global myocardial T1 times (1.5 T then 3 T results) were significantly longer by diastolic SAPPHIRE (1283 ± 11|1600 ± 17 ms) than any of the other SAPPHIRE variants: systolic (1239 ± 9|1595 ± 13 ms), 0th order DB (1241 ± 10|1596 ± 12) and 2nd order DB (1251 ± 11|1560 ± 20 ms, all p < 0.05). In the mid septum MOLLI and diastolic SAPPHIRE exhibited significant T1 signal contamination (longer T1) at the blood-myocardial interface not seen with the other 3 SAPPHIRE variants (all p < 0.025). Additionally, systolic, 0th order and 2nd order DB SAPPHIRE showed narrower dispersion of myocardial T1 times across the mid septum when compared to diastolic SAPPHIRE (interquartile ranges respectively: 25 ms, 71 ms, 73 ms vs 143 ms, all p < 0.05). RV T1 mapping was achievable using systolic, 0th and 2nd order DB SAPPHIRE but not with MOLLI or diastolic SAPPHIRE. All 4 SAPPHIRE variants showed excellent re-read reproducibility (intraclass correlation coefficients 0.953 to 0.996). Conclusion: These small-scale preliminary healthy volunteer data suggest that DB SAPPHIRE has the potential to reduce partial volume effects at the blood-myocardial interface, and that systolic SAPPHIRE could be a feasible solution for right ventricular T1 mapping. Further work is needed to understand the robustness of these sequences and their potential clinical utility.
Subject
Cardiovascular magnetic resonance
MOLLI
SAPPHIRE
T1 mapping
To reference this document use:
http://resolver.tudelft.nl/uuid:43f357e5-df68-4a43-bfe7-759c70d21b27
DOI
https://doi.org/10.1186/s12880-022-00843-0
ISSN
1471-2342
Source
BMC Medical Imaging, 22 (1)
Part of collection
Institutional Repository
Document type
journal article
Rights
© 2022 Mashael Alfarih, João B. Augusto, Kristopher D. Knott, Nasri Fatih, M. Praveen Kumar, Redha Boubertakh, Alun D. Hughes, James C. Moon, S.D. Weingärtner, Gabriella Captur