Print Email Facebook Twitter Enzymatic Bromocyclization of α- and γ-Allenols by Chloroperoxidase from Curvularia inaequalis Title Enzymatic Bromocyclization of α- and γ-Allenols by Chloroperoxidase from Curvularia inaequalis Author Naapuri, Janne M. (Aalto University) Wagner, Philip K. (Aalto University; University of Cologne) Hollmann, F. (TU Delft BT/Biocatalysis) Deska, Jan (Aalto University) Date 2022 Abstract Vanadate-dependent chloroperoxidase from Curvularia inaequalis catalyzes 5-endo-trig bromocyclizations of α-allenols to produce valuable halofunctionalized furans as versatile synthetic building blocks. In contrast to other haloperoxidases, also the more challenging 5-exo-trig halocyclizations of γ-allenols succeed with this system even though the scope still remains more narrow. Benefitting from the vanadate chloroperoxidase‘s high resiliency towards oxidative conditions, cyclization-inducing reactive hypohalite species are generated in situ from bromide salts and hydrogen peroxide. Crucial requirements for high conversions are aqueous biphasic emulsions as reaction media, stabilized by either cationic or non-ionic surfactants. To reference this document use: http://resolver.tudelft.nl/uuid:4eb2fba8-040b-487e-b6f7-2056b2817462 DOI https://doi.org/10.1002/open.202100236 Source ChemistryOpen, 11 (1) Part of collection Institutional Repository Document type journal article Rights © 2022 Janne M. Naapuri, Philip K. Wagner, F. Hollmann, Jan Deska Files PDF ChemistryOpen_2022_Naapur ... ularia.pdf 2.2 MB Close viewer /islandora/object/uuid:4eb2fba8-040b-487e-b6f7-2056b2817462/datastream/OBJ/view