Print Email Facebook Twitter Identification of Atrial Transmural Conduction Inhomogeneity Using Unipolar Electrogram Morphology Title Identification of Atrial Transmural Conduction Inhomogeneity Using Unipolar Electrogram Morphology Author Zhang, Lu (Erasmus MC) van Schie, M.S. (Erasmus MC) Xiang, Hongxian (Erasmus MC) Liao, Rongheng (Erasmus MC) Zheng, Jiahao (Erasmus MC) Knops, Paul (Erasmus MC) Taverne, Yannick J.H.J. (Erasmus MC) de Groot, N.M.S. (TU Delft Signal Processing Systems; Erasmus MC) Date 2024 Abstract (1) Background: Structural remodeling plays an important role in the pathophysiology of atrial fibrillation (AF). It is likely that structural remodeling occurs transmurally, giving rise to electrical endo-epicardial asynchrony (EEA). Recent studies have suggested that areas of EEA may be suitable targets for ablation therapy of AF. We hypothesized that the degree of EEA is more pronounced in areas of transmural conduction block (T-CB) than single-sided CB (SS-CB). This study examined the degree to which SS-CB and T-CB enhance EEA and which specific unipolar potential morphology parameters are predictive for SS-CB or T-CB. (2) Methods: Simultaneous endo-epicardial mapping in the human right atrium was performed in 86 patients. Potential morphology parameters included unipolar potential voltages, low-voltage areas, potential complexity (long double and fractionated potentials: LDPs and FPs), and the duration of fractionation. (3) Results: EEA was mostly affected by the presence of T-CB areas. Lower potential voltages and more LDPs and FPs were observed in T-CB areas compared to SS-CB areas. (4) Conclusion: Areas of T-CB could be most accurately predicted by combining epicardial unipolar potential morphology parameters, including voltages, fractionation, and fractionation duration (AUC = 0.91). If transmural areas of CB indeed play a pivotal role in the pathophysiology of AF, they could theoretically be used as target sites for ablation. Subject electrogramsendo-epicardial delaysimultaneous endo-epicardial mappingsinus rhythmtransmural conduction block To reference this document use: http://resolver.tudelft.nl/uuid:64ae1a0e-9e13-4ba9-a2ed-b61eafce12c6 DOI https://doi.org/10.3390/jcm13041015 Source Journal of Clinical Medicine, 13 (4) Part of collection Institutional Repository Document type journal article Rights © 2024 Lu Zhang, M.S. van Schie, Hongxian Xiang, Rongheng Liao, Jiahao Zheng, Paul Knops, Yannick J.H.J. Taverne, N.M.S. de Groot Files PDF jcm-13-01015-v2.pdf 4.86 MB Close viewer /islandora/object/uuid:64ae1a0e-9e13-4ba9-a2ed-b61eafce12c6/datastream/OBJ/view