Hydrogenation and hydrogenolysis in synthetic organic chemistry

Hydrogenation and hydrogenolysis in synthetic organic chemistry

Kieboom, A.P.G.
Van Rantwijk, F.

Van Bekkum, H.

Applied Sciences

1977-12-31

The major aim of this book is to provide preparative organic chemists with the insight and the know-how necessary to apply catalytic hydrogenation and hydrogenolysis to synthetic problems. Several texts on hydrogenation and hydrogenolysis are available, but the authors feel that many chemists will welcome a book in which more attention has been paid to the mechanistic background of these reactions and its relation to synthetic problems. In this book a special effort has been made to present the various types of hydrogenation and hydrogenolysis reactions from both a mechanistic and a preparative point of view. After a short general introduction concerning catalyst systems and reaction conditions, hydrogenation and hydrogenolysis are discussed separately. The chapters have been organized according to a logical arrangement of the various bonds which can be reduced with hydrogen in the presence of a catalyst system. Reaction rate, selectivity, and steric course of the hydrogen addition are dealt with in relation to the reaction mechanism. Numerous synthetically interesting examples exemplify these aspects as well as the scope and limitations of the reactions.

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(c) 1977 Nijgh-Wolters-Noordhoff Universitaire Uitgevers B.V., Rotterdam