Redox-Controlled Shunts in a Synthetic Chemical Reaction Cycle

Title

Redox-Controlled Shunts in a Synthetic Chemical Reaction Cycle

 Author

Sharko, Anastasiia (University of Strasbourg)
Spitzbarth, B. (TU Delft ChemE/Advanced Soft Matter)
Hermans, Thomas M. (University of Strasbourg)
Eelkema, R. (TU Delft ChemE/Advanced Soft Matter) ORCID 0000-0002-2626-6371

 Date

2023

 Abstract

Shunts, alternative pathways in chemical reaction networks (CRNs), are ubiquitous in nature, enabling adaptability to external and internal stimuli. We introduce a CRN in which the recovery of Michael-accepting species is driven by oxidation chemistry. Using weak oxidants can enable access to two shunts within this CRN with different kinetics and a reduced number of side reactions compared to the main cycle that is driven by strong oxidants. Furthermore, we introduce a strategy to recycle one of the main products under flow conditions to partially reverse the CRN and control product speciation throughout time. These findings introduce new levels of control over artificial CRNs, driven by redox chemistry, narrowing the gap between synthetic and natural systems.


 To reference this document use:

http://resolver.tudelft.nl/uuid:88fb90e4-70e1-4670-9240-579a0686e6d4

 DOI

https://doi.org/10.1021/jacs.3c00985

 ISSN

0002-7863

 Source

Journal of the American Chemical Society, 145 (17), 9672-9678

 Part of collection

Institutional Repository

 Document type

journal article

 Rights

© 2023 Anastasiia Sharko, B. Spitzbarth, Thomas M. Hermans, R. Eelkema
Files
PDF jacs.3c00985.pdf 2.83 MB
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