Modeling the brain morphology distribution in the general aging population

Modeling the brain morphology distribution in the general aging population

Huizinga, W. (Erasmus MC)
Poot, D.H.J. (TU Delft ImPhys/Quantitative Imaging; Erasmus MC)
Roshchupkin, G. (Erasmus MC)
Bron, E. E. (Erasmus MC)
Ikram, M. A. (Erasmus MC)
Vernooij, M. W. (Erasmus MC)
Rueckert, D. (Imperial College London)
Niessen, W.J. (TU Delft ImPhys/Quantitative Imaging; Erasmus MC)
Klein, S. (Erasmus MC)

Gimi, Barjor (editor)
Krol, Andrzej (editor)

2016

Both normal aging and neurodegenerative diseases such as Alzheimer's disease cause morphological changes of the brain. To better distinguish between normal and abnormal cases, it is necessary to model changes in brain morphology owing to normal aging. To this end, we developed a method for analyzing and visualizing these changes for the entire brain morphology distribution in the general aging population. The method is applied to 1000 subjects from a large population imaging study in the elderly, from which 900 were used to train the model and 100 were used for testing. The results of the 100 test subjects show that the model generalizes to subjects outside the model population. Smooth percentile curves showing the brain morphology changes as a function of age and spatiotemporal atlases derived from the model population are publicly available via an interactive web application at agingbrain.bigr.nl.

LMS method
Non-rigid groupwise registration
Partial least squares regression
Spatiotemporal atlas
Statistical modeling

http://resolver.tudelft.nl/uuid:8b1b0770-221a-41e2-ab8d-7e59de7a79a4

https://doi.org/10.1117/12.2207228

SPIE

978-1-510600232

Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging, 9788

Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging, 2016-03-01 → 2016-03-03, San Diego, United States

Proceedings of SPIE, 1605-7422, 9788

Institutional Repository

conference paper

© 2016 W. Huizinga, D.H.J. Poot, G. Roshchupkin, E. E. Bron, M. A. Ikram, M. W. Vernooij, D. Rueckert, W.J. Niessen, S. Klein