MI
M. Arfan Ikram
Authored
20 records found
Enlarged perivascular spaces in brain MRI
Automated quantification in four regions
Enlarged perivascular spaces (PVS) are structural brain changes visible in MRI, are common in aging, and are considered a reflection of cerebral small vessel disease. As such, assessing the burden of PVS has promise as a brain imaging marker. Visual and manual scoring of PVS is a
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Age-dependent association of thyroid function with brain morphology and microstructural organization
Evidence from brain imaging
Thyroid hormone (TH) is crucial during neurodevelopment, but high levels of TH have been linked to neurodegenerative disorders. No data on the association of thyroid function with brain imaging in the general population are available. We therefore investigated the association of
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HASE
Framework for efficient high-dimensional association analyses
High-throughput technology can now provide rich information on a person's biological makeup and environmental surroundings. Important discoveries have been made by relating these data to various health outcomes in fields such as genomics, proteomics, and medical imaging. However,
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Trajectories of imaging markers in brain aging
The Rotterdam Study
With aging, the brain undergoes several structural changes. These changes reflect the normal aging process and are therefore not necessarily pathologic. In fact, better understanding of these normal changes is an important cornerstone to also disentangle pathologic changes. Sever
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Resistance to developing brain pathology due to vascular risk factors
The role of educational attainment
Brain pathology develops at different rates between individuals with similar burden of risk factors, possibly explained by brain resistance. We examined if education contributes to brain resistance by studying its influence on the association between vascular risk factors and bra
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White-matter microstructure and hearing acuity in older adults
A population-based cross-sectional DTI study
To study the relation between the microstructure of white matter in the brain and hearing function in older adults we carried out a population-based, cross-sectional study. In 2562 participants of the Rotterdam Study, we conducted diffusion tensor imaging to determine the microst
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Retinal neurodegeneration and brain MRI markers
The Rotterdam Study
We investigated the association of specific retinal sublayer thicknesses on optical coherence tomography (OCT) with brain magnetic resonance imaging (MRI) markers. We included 2124 persons (mean age 67.0 years; 56% women) from the Rotterdam Study who had gradable retinal OCT imag
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Retinal neurodegeneration and brain MRI markers
The Rotterdam Study
We investigated the association of specific retinal sublayer thicknesses on optical coherence tomography (OCT) with brain magnetic resonance imaging (MRI) markers. We included 2124 persons (mean age 67.0 years; 56% women) from the Rotterdam Study who had gradable retinal OCT imag
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Brain Volumes and Longitudinal Cognitive Change
A Population-based Study
Objective: To investigate the association of brain volumes, white matter lesion (WML) volumes, and lacunes, with cognitive decline in a population-based cohort of nondemented persons. Methods: Within the Rotterdam Study, 3624 participants underwent brain magnetic resonance imagin
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Brain Volumes and Longitudinal Cognitive Change
A Population-based Study
Objective: To investigate the association of brain volumes, white matter lesion (WML) volumes, and lacunes, with cognitive decline in a population-based cohort of nondemented persons. Methods: Within the Rotterdam Study, 3624 participants underwent brain magnetic resonance imagin
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Thinner retinal layers are associated with changes in the visual pathway
A population-based study
Increasing evidence shows that thinner retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL), assessed on optical coherence tomography (OCT), are reflecting global brain atrophy. Yet, little is known on the relation of these layers with specific brain regions. Using voxe
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Thinner retinal layers are associated with changes in the visual pathway
A population-based study
Increasing evidence shows that thinner retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL), assessed on optical coherence tomography (OCT), are reflecting global brain atrophy. Yet, little is known on the relation of these layers with specific brain regions. Using voxe
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The structural disconnectome
A pathology-sensitive extension of the structural connectome
Brain connectivity is increasingly being studied using connectomes. Typical structural connectome definitions do not directly take white matter pathology into account. Presumably, pathology impedes signal transmission along fibres, leading to a reduction in function. In order to
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Association of Coffee Consumption with MRI Markers and Cognitive Function
A Population-Based Study
Background: Coffee is one of the most widely consumed beverages worldwide and has been of considerable interest in research on cognition and dementia. Objective: To investigate the effect of coffee on preclinical brain MRI markers of dementia and cognitive performance. Methods: I
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Automatic normative quantification of brain tissue volume to support the diagnosis of dementia
A clinical evaluation of diagnostic accuracy
Objectives: To assesses whether automated brain image analysis with quantification of structural brain changes improves diagnostic accuracy in a memory clinic setting. Methods: In 42 memory clinic patients, we evaluated whether automated quantification of brain tissue volumes, hi
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Gp-Unet
Lesion detection from weak labels with a 3D regression network
We propose a novel convolutional neural network for lesion detection from weak labels. Only a single, global label per image - the lesion count - is needed for training. We train a regression network with a fully convolutional architecture combined with a global pooling layer to
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Background: The combination of genetics and imaging has improved their understanding of the brain through studies of aggregate measures obtained from high-resolution structural imaging. Voxel-wise analyses have the potential to provide more detailed information of genetic influen
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Next-generation sequencing has contributed to our understanding of the genetics of Alzheimer's disease (AD) and has explained a substantial part of the missing heritability of familial AD. We sequenced 19 exomes from 8 Dutch families with a high AD burden and identified EIF2AK3,
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Background and Purpose - The presence of subclinical vascular brain disease, including white matter lesions and lacunar infarcts, substantially increases the risk of clinical stroke. White matter microstructural integrity is considered an earlier, potentially better, marker of th
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Both normal aging and neurodegenerative diseases such as Alzheimer's disease cause morphological changes of the brain. To better distinguish between normal and abnormal cases, it is necessary to model changes in brain morphology owing to normal aging. To this end, we developed a
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