Technology platform for advanced neurostimulation implants

The “chip-in-tip” DBS probe

Doctoral thesis (2022)

Authors

M.M. Kluba Electronic Components, Technology and Materials - EEMCS
Research Group
Electronic Components, Technology and Materials (EEMCS) (TU Delft)
Copyright: © 2022 M.M. Kluba
DOI: https://doi.org/10.4233/uuid:9dd9701b-343e-4f25-8d49-02652e839e32
Miniaturization Ceramics Parylene Platinum Neurostimulation Directional deep brain stimulator High-level integration Trench capacitor High-definition flex-to-rigid Sealable trenches Cavity-BOX Biocompatible flip-chip Flexible interconnects Soft encapsulation Parylene processing in cleanroom
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Published Date

2022

Language

English

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Faculty

Electrical Engineering, Mathematics and Computer Science

Department

Microelectronics

Research Group

Electronic Components, Technology and Materials

Abstract

The progress in the field of neurostimulation is impressive, both from a technical as well as from a therapeutic point of view. Nowadays, the electrical stimulation of the nervous system can be used to induce or suppress muscle responses. Additionally, it can also influence hearing, vision, immune system response, pain perception, and even mental state. The number of medical conditions that can be treated using existing or completely new neurostimulation devices is continuously growing. Moreover, well-targeted electrical neuromodulation can help reduce the whole-body side effects, typical for traditional medication therapies. However, the potential of neurostimulation therapy is limited by the relatively slow development of the accompanying technologies. Most commercial neurostimulation implants still consist of a pulse generator encapsulated in a bulky titanium case and lengthy extension cords. Moreover, in some cases, such as deep brain stimulation (DBS), the resolution of the stimulation is also an issue that can cause severe side effects. In this thesis work, a technology platform for the manufacturing and packaging of advanced neurostimulation implants has been developed to enable further bioelectronics miniaturization and improve the stimulation resolution. These goals have been achieved in close collaboration with the InForMed project partners involved in finalizing the joint design, preparing the inter-facility fabrication process, and supplying off-the-shelf technology modules…