Print Email Facebook Twitter The workings of ferritin: a crossroad of opinions Title The workings of ferritin: a crossroad of opinions Author Hagen, W.R. (TU Delft BT/Biocatalysis) Hagedoorn, P.L. (TU Delft BT/Biocatalysis) Honarmand Ebrahimi, K. (University of Oxford) Date 2017-05 Abstract Biochemistry of the essential element iron is complicated by radical chemistry associated with Fe(II) ions and by the extremely low solubility of the Fe(III) ion in near-neutral water. To mitigate these problems cells from all domains of life synthesize the protein ferritin to take up and oxidize Fe(II) and to form a soluble storage of Fe(III) from which iron can be made available for physiology. A long history of studies on ferritin has not yet resulted in a generally accepted mechanism of action of this enzyme. In fact strong disagreement exists between extant ideas on several key steps in the workings of ferritin. The scope of this review is to explain the experimental background of these controversies and to indicate directions towards their possible resolution. To reference this document use: http://resolver.tudelft.nl/uuid:a02b191c-75b1-483f-bb9d-43ba29b86773 DOI https://doi.org/10.1039/C7MT00124J ISSN 1756-5901 Source Metallomics: integrated biometal science Part of collection Institutional Repository Document type journal article Rights © 2017 W.R. Hagen, P.L. Hagedoorn, K. Honarmand Ebrahimi Files PDF c7mt00124j.pdf 2.71 MB Close viewer /islandora/object/uuid:a02b191c-75b1-483f-bb9d-43ba29b86773/datastream/OBJ/view