Print Email Facebook Twitter Comparison of fan-beam, slit-slat and multi-pinhole collimators for molecul breast tomosynthesis Title Comparison of fan-beam, slit-slat and multi-pinhole collimators for molecul breast tomosynthesis Author van Roosmalen, J. (TU Delft RST/Biomedical Imaging) Beekman, F.J. (TU Delft RST/Biomedical Imaging; MILabs B.V.) Goorden, M.C. (TU Delft RST/Biomedical Imaging) Date 2018 Abstract Recently, we proposed and optimized dedicated multi-pinhole molecular breast tomosynthesis (MBT) that images a lightly compressed breast. As MBT may also be performed with other types of collimators, the aim of this paper is to optimize MBT with fan beam and slit-slat collimators and to compare its performance to that of multi-pinhole MBT to arrive at a truly optimized design. Using analytical expressions, we first optimized fan beam and slit-slat collimator parameters to reach maximum sensitivity at a series of given system resolutions. Additionally, we performed full system simulations of a breast phantom containing several tumours for the optimized designs. We found that at equal system resolution the maximum achievable sensitivity increases from pinhole to slit-slat to fan beam collimation with fan beam and slit-slat MBT having on average a 48% and 20% higher sensitivity than multi-pinhole MBT. Furthermore, by inspecting simulated images and applying a tumour-to-background contrast-to-noise (TB-CNR) analysis, we found that slit-slat collimators underperform with respect to the other collimator types. The fan beam collimators obtained a similar TB-CNR as the pinhole collimators, but the optimum was reached at different system resolutions. For fan beam collimators, a 6–8 mm system resolution was optimal in terms of TB-CNR, while with pinhole collimation highest TB-CNR was reached in the 7–10 mm range. To reference this document use: http://resolver.tudelft.nl/uuid:a2c77608-ee98-4d77-b040-ec25832ce20b DOI https://doi.org/10.1088/1361-6560/aabfa3 Embargo date 2018-11-16 ISSN 0094-2405 Source Medical Physics, 63 Bibliographical note Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public. Part of collection Institutional Repository Document type journal article Rights © 2018 J. van Roosmalen, F.J. Beekman, M.C. Goorden Files PDF van_Roosmalen_2018_Phys._ ... averne.pdf 2.63 MB Close viewer /islandora/object/uuid:a2c77608-ee98-4d77-b040-ec25832ce20b/datastream/OBJ/view