Print Email Facebook Twitter Reconstructing 3D proton dose distribution using ionoacoustics Title Reconstructing 3D proton dose distribution using ionoacoustics Author van Dongen, K.W.A. (TU Delft ImPhys/Acoustical Wavefield Imaging) de Blécourt, A.J. (TU Delft ImPhys/Acoustical Wavefield Imaging) Lens, E. (TU Delft RST/Medical Physics & Technology) Schaart, D.R. (TU Delft RST/Medical Physics & Technology) Vos, F.M. (TU Delft ImPhys/Quantitative Imaging) Date 2019 Abstract In proton therapy high energy protons are used to irradiate a tumor. Ideally, the delivered proton dose distribution is measured during treatment to ensure patient safety and treatment effectiveness. Here we investigate if we can use the ionoacoustic wave field to monitor the actual proton dose distribution for the two most commonly used proton accelerators; the isochronous cyclotron and the synchrocyclotron. To this end we model the acoustic field generated by the protons when irradiating a heterogeneous cancerous breast with a 89 MeV proton beam. To differentiate between the systems, idealized temporal micro-structures of the beams have been implemented. Results show that by employing model-based inversion we are able to reconstruct the 3D dose distributions from the simulated noisy pressure fields. Good results are obtained for both systems; the absolute error in the position of the maximum amplitude of the dose distribution is 5.0 mm for the isochronous cyclotron and 5.2 mm for the synchrocyclotron. In conclusion, this numerical study suggests that the ionoacoustic wave field may be used to monitor the proton dose distribution during breast cancer treatment. Subject 3D inversionBragg peakproton range verificationionoacoustics To reference this document use: http://resolver.tudelft.nl/uuid:a765a495-5f2a-431a-953b-292daf0ad764 DOI https://doi.org/10.1088/1361-6560/ab4cd5 Embargo date 2020-05-15 ISSN 0031-9155 Source Physics in Medicine and Biology, 64 (22) Bibliographical note Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public. Part of collection Institutional Repository Document type journal article Rights © 2019 K.W.A. van Dongen, A.J. de Blécourt, E. Lens, D.R. Schaart, F.M. Vos Files PDF van_Dongen_2019_Phys._Med ... averne.pdf 2.31 MB Close viewer /islandora/object/uuid:a765a495-5f2a-431a-953b-292daf0ad764/datastream/OBJ/view