Print Email Facebook Twitter Continuous downstream processing Title Continuous downstream processing Author Jungbauer, Alois (BOKU-University of Natural Resources and Life Sciences; Austrian Centre of Industrial Biotechnology (ACIB GmbH)) Satzer, Peter (BOKU-University of Natural Resources and Life Sciences; Austrian Centre of Industrial Biotechnology GmbH) Duerauer, Astrid (BOKU-University of Natural Resources and Life Sciences; Austrian Centre of Industrial Biotechnology GmbH) Azevedo, Ana (Lisbon Technical University) Aires-Barros, Raquel (Lisbon Technical University) Nilsson, Bernt (Lund University) Farid, Suzy (University College London (UCL)) Goldrick, Stephen (University College London (UCL)) Ottens, M. (TU Delft BT/Design and Engineering Education) Date 2024-06-19 Abstract The main objectives of bioprocesses are to reliably deliver drugs in a relatively short time frame with high quality within a tight regulatory framework. Bioprocesses are highly complex, the level of automation is moderate, and there is constant pressure to improve efficiency and costs. In addition, climate change and resource scarcity mandate a reduction in the environmental footprint of bioprocesses and production facilities. In the biopharmaceutical industry, two extreme production scenarios are applied: a fully disposable factory with the characteristics of full flexibility and speed, or a fixed large-scale plant with high capacity. Forward-looking solutions and ideas will be discussed how to combine new processes and environmental friendliness for the benefit of the patient, security of supply and profitability. The concept will be extended to large scale production of proteins for food and non-pharma applications, e.g., in material science and a roadmap towards a future plant will be laid out. Subject Continuous integrated biomanufacturingEconomicsEnvironmental footprintMicrofluidicsScale down To reference this document use: http://resolver.tudelft.nl/uuid:b823d8ae-07a8-4bda-a523-3f752926edc6 DOI https://doi.org/10.1016/j.seppur.2024.126439 ISSN 1383-5866 Source Separation and Purification Technology, 338 Part of collection Institutional Repository Document type review Rights © 2024 Alois Jungbauer, Peter Satzer, Astrid Duerauer, Ana Azevedo, Raquel Aires-Barros, Bernt Nilsson, Suzy Farid, Stephen Goldrick, M. Ottens, More Authors Files PDF 1-s2.0-S1383586624001783-main.pdf 2.72 MB Close viewer /islandora/object/uuid:b823d8ae-07a8-4bda-a523-3f752926edc6/datastream/OBJ/view