Print Email Facebook Twitter Influence of aortic aneurysm on the local distribution of NO and O2 using image-based computational fluid dynamics Title Influence of aortic aneurysm on the local distribution of NO and O2 using image-based computational fluid dynamics Author Perinajová, R. (TU Delft ChemE/Transport Phenomena; J.M. Burgers Centre for Fluid Mechanics) Álvarez-Cuevas, Concepción Borrás (Student TU Delft) Juffermans, Joe (Leiden University Medical Center) Westenberg, Jos (Leiden University Medical Center) Lamb, Hildo (Leiden University Medical Center) Kenjeres, S. (TU Delft ChemE/Transport Phenomena; J.M. Burgers Centre for Fluid Mechanics) Date 2023 Abstract There is a pressing need to establish novel biomarkers to predict the progression of thoracic aortic aneurysm (TAA) dilatation. Aside from hemodynamics, the roles of oxygen (O2) and nitric oxide (NO) in TAA pathogenesis are potentially significant. As such, it is imperative to comprehend the relationship between aneurysm presence and species distribution in both the lumen and aortic wall. Given the limitations of existing imaging methods, we propose the use of patient-specific computational fluid dynamics (CFD) to explore this relationship. We have performed CFD simulations of O2 and NO mass transfer in the lumen and aortic wall for two cases: a healthy control (HC) and a patient with TAA, both acquired using 4D-flow magnetic resonance imaging (MRI). The mass transfer of O2 was based on active transport by hemoglobin, while the local variations of the wall shear stress (WSS) drove NO production. Comparing hemodynamic properties, the time-averaged WSS was considerably lower for TAA, while the oscillatory shear index and endothelial cell activation potential were notably elevated. O2 and NO showed a non-uniform distribution within the lumen and an inverse correlation between the two species. We identified several locations of hypoxic regions for both cases due to lumen-side mass transfer limitations. In the wall, NO varied spatially, with a clear distinction between TAA and HC. In conclusion, the hemodynamics and mass transfer of NO in the aorta exhibit the potential to serve as a diagnostic biomarker for TAA. Furthermore, hypoxia may provide additional insights into the onset of other aortic pathologies. Subject 4D-flow MRIBiomarkersCFDNitric oxideOxygenTAA To reference this document use: http://resolver.tudelft.nl/uuid:ba9e0502-8fbe-4173-8c27-551661fc8049 DOI https://doi.org/10.1016/j.compbiomed.2023.106925 ISSN 0010-4825 Source Computers in Biology and Medicine, 160 Part of collection Institutional Repository Document type journal article Rights © 2023 R. Perinajová, Concepción Borrás Álvarez-Cuevas, Joe Juffermans, Jos Westenberg, Hildo Lamb, S. Kenjeres Files PDF 1_s2.0_S0010482523003906_main.pdf 4.06 MB Close viewer /islandora/object/uuid:ba9e0502-8fbe-4173-8c27-551661fc8049/datastream/OBJ/view