Title
Current models to understand the onset and progression of scoliotic deformities in adolescent idiopathic scoliosis: a systematic review
Author
Meiring, A. R. (Student TU Delft)
de Kater, E.P. (TU Delft Medical Instruments & Bio-Inspired Technology; TU Delft Sports & Games) 
Stadhouder, A. (Amsterdam UMC; Amsterdam Movement Sciences)
van Royen, B. J. (Universiteit van Amsterdam; Amsterdam UMC; Amsterdam Movement Sciences)
Breedveld, P. (TU Delft Medical Instruments & Bio-Inspired Technology)
Smit, T. H. (Amsterdam UMC; Amsterdam Movement Sciences)
Date
2023
Abstract
Purpose: To create an updated and comprehensive overview of the modeling studies that have been done to understand the mechanics underlying deformities of adolescent idiopathic scoliosis (AIS), to predict the risk of curve progression and thereby substantiate etiopathogenetic theories. Methods: In this systematic review, an online search in Scopus and PubMed together with an analysis in secondary references was done, which yielded 86 studies. The modeling types were extracted and the studies were categorized accordingly. Results: Animal modeling, together with machine learning modeling, forms the category of black box models. This category is perceived as the most clinically relevant. While animal models provide a tangible idea of the biomechanical effects in scoliotic deformities, machine learning modeling was found to be the best curve-progression predictor. The second category, that of artificial models, has, just as animal modeling, a tangible model as a result, but focusses more on the biomechanical process of the scoliotic deformity. The third category is formed by computational models, which are very popular in etiopathogenetic parameter-based studies. They are also the best in calculating stresses and strains on vertebrae, intervertebral discs, and other surrounding tissues. Conclusion: This study presents a comprehensive overview of the current modeling techniques to understand the mechanics of the scoliotic deformities, predict the risk of curve progression in AIS and thereby substantiate etiopathogenetic theories. Although AIS remains to be seen as a complex and multifactorial problem, the progression of its deformity can be predicted with good accuracy. Modeling of AIS develops rapidly and may lead to the identification of risk factors and mitigation strategies in the near future. The overview presented provides a basis to follow this development.
Subject
Adolescent idiopathic scoliosis
Biomechanics
Curve progression
Modeling
Pathogenesis
To reference this document use:
http://resolver.tudelft.nl/uuid:c7fd77b8-cfdb-4f24-86a9-19774cf41955
DOI
https://doi.org/10.1007/s43390-022-00618-1
Embargo date
2023-07-01
ISSN
2212-134X
Source
Spine Deformity, 11 (3), 545-558
Bibliographical note
Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.
Part of collection
Institutional Repository
Document type
review
Rights
© 2023 A. R. Meiring, E.P. de Kater, A. Stadhouder, B. J. van Royen, P. Breedveld, T. H. Smit