Print Email Facebook Twitter Epigenetic and Metabolomic Biomarkers for Biological Age Title Epigenetic and Metabolomic Biomarkers for Biological Age: A Comparative Analysis of Mortality and Frailty Risk Author Kuiper, L.M. (TU Delft Pattern Recognition and Bioinformatics; Erasmus MC; Center for Nutrition) Polinder-Bos, Harmke A. (Erasmus MC) Bizzarri, D. (TU Delft Pattern Recognition and Bioinformatics; Leiden University Medical Center) Vojinovic, Dina (Leiden University Medical Center; Erasmus MC) Vallerga, Costanza L. (Erasmus MC) Reinders, M.J.T. (TU Delft Pattern Recognition and Bioinformatics; Leiden University Medical Center) Slagboom, P. Eline (Leiden University Medical Center; Max Planck Institute for Biology of Ageing) van den Akker, E.B. (TU Delft Pattern Recognition and Bioinformatics; Leiden University Medical Center) Date 2023 Abstract Biological age captures a person's age-related risk of unfavorable outcomes using biophysiological information. Multivariate biological age measures include frailty scores and molecular biomarkers. These measures are often studied in isolation, but here we present a large-scale study comparing them. In 2 prospective cohorts (n = 3 222), we compared epigenetic (DNAm Horvath, DNAm Hannum, DNAm Lin, DNAm epiTOC, DNAm PhenoAge, DNAm DunedinPoAm, DNAm GrimAge, and DNAm Zhang) and metabolomic-based (MetaboAge and MetaboHealth) biomarkers in reflection of biological age, as represented by 5 frailty measures and overall mortality. Biomarkers trained on outcomes with biophysiological and/or mortality information outperformed age-trained biomarkers in frailty reflection and mortality prediction. DNAm GrimAge and MetaboHealth, trained on mortality, showed the strongest association with these outcomes. The associations of DNAm GrimAge and MetaboHealth with frailty and mortality were independent of each other and of the frailty score mimicking clinical geriatric assessment. Epigenetic, metabolomic, and clinical biological age markers seem to capture different aspects of aging. These findings suggest that mortality-trained molecular markers may provide novel phenotype reflecting biological age and strengthen current clinical geriatric health and well-being assessment. Subject DNA methylationFrailtyMortality To reference this document use: http://resolver.tudelft.nl/uuid:ce390c31-6c9b-465a-a960-1720c1354d24 DOI https://doi.org/10.1093/gerona/glad137 ISSN 1079-5006 Source Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 78 (10), 1753-1762 Part of collection Institutional Repository Document type journal article Rights © 2023 L.M. Kuiper, Harmke A. Polinder-Bos, D. Bizzarri, Dina Vojinovic, Costanza L. Vallerga, M.J.T. Reinders, P. Eline Slagboom, E.B. van den Akker, More Authors Files PDF glad137.pdf 3.69 MB Close viewer /islandora/object/uuid:ce390c31-6c9b-465a-a960-1720c1354d24/datastream/OBJ/view