Real-time volumetric lipid imaging in vivo by intravascular photoacoustics at 20 frames per second

Journal article (2017)

Authors

Min Wu Erasmus MC
Geert Springeling Erasmus MC
M. Lovrak ChemE/Advanced Soft Matter - AS
Frits Mastik Erasmus MC
Tianshi Wang Erasmus MC
A.F.W. van der Steen , Erasmus MC, Chinese Academy of Sciences
G. van Soest Erasmus MC
Research Group
ChemE/Advanced Soft Matter (AS) (TU Delft)
Copyright: © 2017 Min Wu, Geert Springeling, M. Lovrak, Frits Mastik, Sophinese Iskander-Rizk, Tianshi Wang, Heleen M.M. Van Beusekom, A.F.W. van der Steen, G. van Soest
DOI: https://doi.org/10.1364/BOE.8.000943
Photoacoustic imaging Imaging systems
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Published Date

01-02-2017

Language

English

Faculty

Applied Sciences

Department

ChemE/Chemical Engineering

Research Group

ChemE/Advanced Soft Matter

Abstract

Lipid deposition can be assessed with combined intravascular photoacoustic/ultrasound (IVPA/US) imaging. To date, the clinical translation of IVPA/US imaging has been stalled by a low imaging speed and catheter complexity. In this paper, we demonstrate imaging of lipid targets in swine coronary arteries in vivo, at a clinically useful frame rate of 20 s−1. We confirmed image contrast for atherosclerotic plaque in human samples ex vivo. The system is on a mobile platform and provides real-time data visualization during acquisition. We achieved an IVPA signal-to-noise ratio of 20 dB. These data show that clinical translation of IVPA is possible in principle.