Print Email Facebook Twitter A Geant4 based simulation platform of the HollandPTC R&D proton beamline for radiobiological studies Title A Geant4 based simulation platform of the HollandPTC R&D proton beamline for radiobiological studies Author Groenendijk, C.F. (TU Delft RST/Medical Physics & Technology) Rovituso, M. (Holland Proton Therapy Centre) Lathouwers, D. (TU Delft RST/Reactor Physics and Nuclear Materials) Brown, J.M.C. (TU Delft RST/Medical Physics & Technology; Swinburne University of Technology) Date 2023 Abstract A Geant4 based simulation platform of the Holland Proton Therapy Centre (HollandPTC, Netherlands) R&D beamline (G4HPTC-R&D) was developed to enable the planning, optimisation and advanced dosimetry for radiobiological studies. It implemented a six parameter non-symmetrical Gaussian pencil beam surrogate model to simulate the R&D beamline in both a pencil beam and passively scattered field configuration. Three different experimental proton datasets (70 MeV, 150 MeV, and 240 MeV) of the pencil beam envelope evolution in free air and depth-dose profiles in water were used to develop a set of individual parameter surrogate functions to enable the modelling of the non-symmetrical Gaussian pencil beam properties with only the ProBeam isochronous cyclotron mean extraction proton energy as input. This refined beam model was then benchmarked with respect to three independent experimental datasets of the R&D beamline operating in both a pencil beam configuration at 120 and 200 MeV, and passively scattered field configuration at 150 MeV. It was shown that the G4HPTC-R&D simulation platform can reproduce the pencil beam envelope evolution in free air and depth-dose profiles to within an accuracy on the order of ±5% for all tested energies, and that it was able to reproduce the 150 MeV passively scattered field to the specifications need for clinical and radiobiological applications. Subject Geant4HollandPTCProton radiotherapyRadiobiologyRadiotherapy To reference this document use: http://resolver.tudelft.nl/uuid:e5ef3356-54be-4126-9bb2-9602dd281757 DOI https://doi.org/10.1016/j.ejmp.2023.102643 ISSN 1120-1797 Source Physica Medica: an international journal devoted to the applications of physics to medicine and biology, 112 Part of collection Institutional Repository Document type journal article Rights © 2023 C.F. Groenendijk, M. Rovituso, D. Lathouwers, J.M.C. Brown Files PDF 1_s2.0_S1120179723001205_main.pdf 2.12 MB Close viewer /islandora/object/uuid:e5ef3356-54be-4126-9bb2-9602dd281757/datastream/OBJ/view