Functional Synthetic Biology

Functional Synthetic Biology

Aldulijan, Ibrahim (Stevens Institute of Technology)
Beal, Jacob (Intelligent Software & Systems, Raytheon BBN Technologies, Cambridge)
Billerbeck, Sonja (Rijksuniversiteit Groningen)
Bouffard, Jeff (Concordia University)
Chambonnier, Gaël (Massachusetts Institute of Technology)
Ntelkis, Nikolaos (Universiteit Gent)
Guerreiro, Isaac (iGEM Foundation, Cambridge)
Holub, M. (TU Delft BN/Cees Dekker Lab)
Ross, Paul (BioStrat Marketing, Boynton Beach)

2023

Synthetic biologists have made great progress over the past decade in developing methods for modular assembly of genetic sequences and in engineering biological systems with a wide variety of functions in various contexts and organisms. However, current paradigms in the field entangle sequence and functionality in a manner that makes abstraction difficult, reduces engineering flexibility and impairs predictability and design reuse. Functional Synthetic Biology aims to overcome these impediments by focusing the design of biological systems on function, rather than on sequence. This reorientation will decouple the engineering of biological devices from the specifics of how those devices are put to use, requiring both conceptual and organizational change, as well as supporting software tooling. Realizing this vision of Functional Synthetic Biology will allow more flexibility in how devices are used, more opportunity for reuse of devices and data, improvements in predictability and reductions in technical risk and cost.

Collaboration
Design
Engineering
Reproducibility
Synthetic Biology

http://resolver.tudelft.nl/uuid:ef07dc0e-37f4-4b1a-9e65-7bc55c6db39b

https://doi.org/10.1093/synbio/ysad006

1939-7267

Synthetic Biology, 8 (1)

Institutional Repository

review

© 2023 Ibrahim Aldulijan, Jacob Beal, Sonja Billerbeck, Jeff Bouffard, Gaël Chambonnier, Nikolaos Ntelkis, Isaac Guerreiro, M. Holub, Paul Ross, More Authors