Mechanisms and clinical importance of bacteriophage resistance

Egido, Julia; Martins Costa, A.R.; Aparicio Maldonado, C.

doi:10.1093/femsre/fuab048

Mechanisms and clinical importance of bacteriophage resistance

Title

Mechanisms and clinical importance of bacteriophage resistance

Author

Egido, Julia (University Medical Center Utrecht)
Martins Costa, A.R. (TU Delft BN/Stan Brouns Lab; Kavli institute of nanoscience Delft)
Aparicio Maldonado, C. (TU Delft BN/Stan Brouns Lab; Kavli institute of nanoscience Delft)

Date

2022

Abstract

We are in the midst of a golden age of uncovering defense systems against bacteriophages. Apart from the fundamentalinterest in these defense systems, and revolutionary applications that have been derived from them (e.g. CRISPR-Cas9 andrestriction endonucleases), it is unknown how defense systems contribute to resistance formation against bacteriophagesin clinical settings. Bacteriophages are now being reconsidered as therapeutic agents against bacterial infections due the
emergence of multidrug resistance. However, bacteriophage resistance through defense systems and other means couldhinder the development of successful phage-based therapies. Here, we review the current state of the field of bacteriophagedefense, highlight the relevance of bacteriophage defense for potential clinical use of bacteriophages as therapeutic agentsand suggest new directions of research.

Subject

phage resistance
phage therapy
innate immunity
adaptive immunity
bacteria
defense

To reference this document use:

http://resolver.tudelft.nl/uuid:f04775d7-a9ec-48cf-a555-995b3725c9ac

DOI

https://doi.org/10.1093/femsre/fuab048

ISSN

0168-6445

Source

FEMS Microbiology Reviews, 46 (1)

Part of collection

Institutional Repository