Print Email Facebook Twitter Dedicated holmium microsphere administration device for MRI-guided interstitial brain microbrachytherapy Title Dedicated holmium microsphere administration device for MRI-guided interstitial brain microbrachytherapy Author de Vries, M. (TU Delft Medical Instruments & Bio-Inspired Technology) Klaassen, N. J.M. (Radboud University Medical Center) Morsink, N. C. (Universiteit Utrecht) van Nimwegen, S. A. (Universiteit Utrecht) Nijsen, J. F.W. (Radboud University Medical Center; Quirem Medical B.V.) van den Dobbelsteen, J.J. (TU Delft Medical Instruments & Bio-Inspired Technology) Date 2021 Abstract Microbrachytherapy with radioactive holmium-166 (166Ho) microspheres (MS) has the potential to be an effective treatment method for brain malignancies. Direct intratumoural delivery of 166Ho-MS and dose coverage of the whole tumour are crucial requirements. However, currently no dedicated instruments for controlled intratumoural delivery exist. This study presents an administration device that facilitates this novel magnetic resonance imaging (MRI) -guided intervention. The bioceramic alumina oxide cannula creates a straight channel for a superelastic nitinol precurved stylet to control spatial deposition of Ho-MS. End-point accuracy of the stylet was measured during insertions in phantoms. Imaging tests were performed in a 3 Tesla MRI-scanner to quantify instrument-induced artefacts. Additionally, the feasibility of non-radioactive holmium-165 (165Ho)-MS delivery with the administration device was evaluated in a brain tumour simulant. Absolute stylet tip error was 0.88 ± 0.61 mm, instrument distortion in MRI depended on needle material and orientation and dose delivery of 165Ho-MS in a brain tumour phantom was possible. This study shows that the administration device can accurately place the stylet for injection of Ho-MS and that visualization can be performed with MRI. Subject BrachytherapyBrain tumourHolmiumImage-guidedSteerable needle To reference this document use: http://resolver.tudelft.nl/uuid:f7cf0dd5-b037-4868-9ee7-d9bbb56c7594 DOI https://doi.org/10.1016/j.medengphy.2021.07.009 Source Medical Engineering & Physics, 96, 13-21 Part of collection Institutional Repository Document type journal article Rights © 2021 M. de Vries, N. J.M. Klaassen, N. C. Morsink, S. A. van Nimwegen, J. F.W. Nijsen, J.J. van den Dobbelsteen Files PDF 1_s2.0_S1350453321000862_main.pdf 2.42 MB Close viewer /islandora/object/uuid:f7cf0dd5-b037-4868-9ee7-d9bbb56c7594/datastream/OBJ/view