Print Email Facebook Twitter Plaque burden is associated with minimal intimal coverage following drug-eluting stent implantation in an adult familial hypercholesterolemia swine model Title Plaque burden is associated with minimal intimal coverage following drug-eluting stent implantation in an adult familial hypercholesterolemia swine model Author Razzi, F. (TU Delft ChemE/Product and Process Engineering) Dijkstra, Jouke (Leiden University Medical Center) Hoogendoorn, Ayla (Erasmus MC) Witberg, Karen (Erasmus MC) Ligthart, Jurgen (Erasmus MC) van Esch, J.H. (TU Delft ChemE/Advanced Soft Matter) van Steijn, V. (TU Delft ChemE/Product and Process Engineering) van Soest, Gijs (Erasmus MC) Regar, Evelyn (Ludwig Maximilians University) Date 2023 Abstract Safety and efficacy of coronary drug-eluting stents (DES) are often preclinically tested using healthy or minimally diseased swine. These generally show significant fibrotic neointima at follow-up, while in patients, incomplete healing is often observed. The aim of this study was to investigate neointima responses to DES in swine with significant coronary atherosclerosis. Adult familial hypercholesterolemic swine (n = 6) received a high fat diet to develop atherosclerosis. Serial OCT was performed before, directly after, and 28 days after DES implantation (n = 14 stents). Lumen, stent and plaque area, uncovered struts, neointima thickness and neointima type were analyzed for each frame and averaged per stent. Histology was performed to show differences in coronary atherosclerosis. A range of plaque size and severity was found, from healthy segments to lipid-rich plaques. Accordingly, neointima responses ranged from uncovered struts, to minimal neointima, to fibrotic neointima. Lower plaque burden resulted in a fibrotic neointima at follow-up, reminiscent of minimally diseased swine coronary models. In contrast, higher plaque burden resulted in minimal neointima and more uncovered struts at follow-up, similarly to patients’ responses. The presence of lipid-rich plaques resulted in more uncovered struts, which underscores the importance of advanced disease when performing safety and efficacy testing of DES. To reference this document use: http://resolver.tudelft.nl/uuid:f8781a2b-6466-42ec-a3e1-c1f7c4388088 DOI https://doi.org/10.1038/s41598-023-37690-0 ISSN 2045-2322 Source Scientific Reports, 13 (1) Part of collection Institutional Repository Document type journal article Rights © 2023 F. Razzi, Jouke Dijkstra, Ayla Hoogendoorn, Karen Witberg, Jurgen Ligthart, J.H. van Esch, V. van Steijn, Gijs van Soest, Evelyn Regar, More Authors Files PDF s41598_023_37690_0.pdf 7.78 MB Close viewer /islandora/object/uuid:f8781a2b-6466-42ec-a3e1-c1f7c4388088/datastream/OBJ/view