Title
Fabrication and characterization of polyimide-based 'smooth' titanium nitride microelectrode arrays for neural stimulation and recording
Author
Oliveira Rodrigues, F.J. (TU Delft Electronic Components, Technology and Materials; University of Minho)
Ribeiro, J.F. (University of Minho)
Anacleto, P.A. (University of Minho)
Fouchard, A. (Grenoble Institute of Neurosciences)
David, O. (Grenoble Institute of Neurosciences)
Sarro, Pasqualina M (TU Delft Electronic Components, Technology and Materials) ![ORCID 0000-0002-2766-0880 ORCID 0000-0002-2766-0880](/sites/all/themes/tud_repo3/img/icons/orcid_16x16.png)
Mendez, P.M. (University of Minho)
Date
2019
Abstract
OBJECTIVE: As electrodes are required to interact with sub-millimeter neural structures, innovative microfabrication processes are required to enable fabrication of microdevices involved in such stimulation and/or recording. This requires the development of highly integrated and miniaturized systems, comprising die-integration-compatible technology and flexible microelectrodes. To elicit selective stimulation and recordings of sub-neural structures, such microfabrication process flow can beneficiate from the integration of titanium nitride (TiN) microelectrodes onto a polyimide substrate. Finally, assembling onto cuffs is required, as well as electrode characterization. APPROACH: Flexible TiN microelectrode array integration and miniaturization was achieved through microfabrication technology based on microelectromechanical systems (MEMS) and complementary metal-oxide semiconductor processing techniques and materials. They are highly reproducible processes, granting extreme control over the feature size and shape, as well as enabling the integration of on-chip electronics. This design is intended to enhance the integration of future electronic modules, with high gains on device miniaturization. MAIN RESULTS: (a) Fabrication of two electrode designs, (1) 2 mm long array with 14 TiN square-shaped microelectrodes (80 × 80 µm2), and (2) an electrode array with 2 mm × 80 µm contacts. The average impedances at 1 kHz were 59 and 5.5 kΩ, respectively, for the smaller and larger contacts. Both designs were patterned on a flexible substrate and directly interconnected with a silicon chip. (b) Integration of flexible microelectrode array onto a cuff electrode designed for acute stimulation of the sub-millimeter nerves. (c) The TiN electrodes exhibited capacitive charge transfer, a water window of -0.6 V to 0.8 V, and a maximum charge injection capacity of 154 ± 16 µC cm-2. SIGNIFICANCE: We present the concept, fabrication and characterization of composite and flexible cuff electrodes, compatible with post-processing and MEMS packaging technologies, which allow for compact integration with control, readout and RF electronics. The fabricated TiN microelectrodes were electrochemically characterized and exhibited a comparable performance to other state-of-the-art electrodes for neural stimulation and recording. Therefore, the presented TiN-on-polyimide microelectrodes, released from silicon wafers, are a promising solution for neural interfaces targeted at sub-millimeter nerves, which may benefit from future upgrades with die-electronic modules.
Subject
peripheral nerve interfaces
nerve cuff electrodes
die-compatible process
titanium nitride electrode
polyimide composite electrodes
sub-millimeter nerves
To reference this document use:
http://resolver.tudelft.nl/uuid:0d29dedb-0554-4e84-8167-e63a472ca874
DOI
https://doi.org/10.1088/1741-2552/ab4dbb
Embargo date
2021-08-02
ISSN
1741-2560
Source
Journal of Neural Engineering, 17 (2020) (1), 1-15
Bibliographical note
Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.
Part of collection
Institutional Repository
Document type
journal article
Rights
© 2019 F.J. Oliveira Rodrigues, J.F. Ribeiro, P.A. Anacleto, A. Fouchard, O. David, Pasqualina M Sarro, P.M. Mendez