Title
Semiautomatic Assessment of the Terminal Ileum and Colon in Patients with Crohn Disease Using MRI (the VIGOR++ Project)
Author
Puylaert, Carl A.J. (Universiteit van Amsterdam)
Schüffler, Peter J. (ETH Zürich; Memorial Sloan-Kettering Cancer Center)
Naziroglu, R.E. (TU Delft ImPhys/Quantitative Imaging)
Tielbeek, Jeroen A.W. (Universiteit van Amsterdam)
Li, Z. (TU Delft ImPhys/Quantitative Imaging; National University of Defense Technology) 
Makanyanga, Jesica C. (University College London)
Tutein Nolthenius, Charlotte J. (Universiteit van Amsterdam)
Nio, C. Yung (Universiteit van Amsterdam)
Pendsé, Douglas A. (University College London)
Menys, Alex (University College London)
Ponsioen, Cyriel Y. (Universiteit van Amsterdam)
Atkinson, David (University College London)
Forbes, Alastair (University of East Anglia)
Buhmann, Joachim M. (ETH Zürich)
Fuchs, Thomas J. (Memorial Sloan-Kettering Cancer Center)
Hatzakis, Haralambos (Biotronics3D Inc.)
van Vliet, L.J. (TU Delft ImPhys/Computational Imaging)
Stoker, Jaap (Universiteit van Amsterdam)
Taylor, Stuart A. (University College London)
Vos, F.M. (TU Delft ImPhys/Quantitative Imaging; Universiteit van Amsterdam)
Date
2018
Abstract
Rationale and Objectives: The objective of this study was to develop and validate a predictive magnetic resonance imaging (MRI) activity score for ileocolonic Crohn disease activity based on both subjective and semiautomatic MRI features. Materials and Methods: An MRI activity score (the “virtual gastrointestinal tract [VIGOR]” score) was developed from 27 validated magnetic resonance enterography datasets, including subjective radiologist observation of mural T2 signal and semiautomatic measurements of bowel wall thickness, excess volume, and dynamic contrast enhancement (initial slope of increase). A second subjective score was developed based on only radiologist observations. For validation, two observers applied both scores and three existing scores to a prospective dataset of 106 patients (59 women, median age 33) with known Crohn disease, using the endoscopic Crohn's Disease Endoscopic Index of Severity (CDEIS) as a reference standard. Results: The VIGOR score (17.1 × initial slope of increase + 0.2 × excess volume + 2.3 × mural T2) and other activity scores all had comparable correlation to the CDEIS scores (observer 1: r = 0.58 and 0.59, and observer 2: r = 0.34–0.40 and 0.43–0.51, respectively). The VIGOR score, however, improved interobserver agreement compared to the other activity scores (intraclass correlation coefficient = 0.81 vs 0.44–0.59). A diagnostic accuracy of 80%–81% was seen for the VIGOR score, similar to the other scores. Conclusions: The VIGOR score achieves comparable accuracy to conventional MRI activity scores, but with significantly improved reproducibility, favoring its use for disease monitoring and therapy evaluation.
Subject
Colon
Crohn disease
Ileum
Image interpretation, computer-assisted
Magnetic resonance imaging
To reference this document use:
http://resolver.tudelft.nl/uuid:0ef4889e-1d34-48d7-961c-cf90a9be662a
DOI
https://doi.org/10.1016/j.acra.2017.12.024
Embargo date
2019-02-08
ISSN
1076-6332
Source
Academic Radiology
Bibliographical note
Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.
Part of collection
Institutional Repository
Document type
journal article
Rights
© 2018 Carl A.J. Puylaert, Peter J. Schüffler, R.E. Naziroglu, Jeroen A.W. Tielbeek, Z. Li, Jesica C. Makanyanga, Charlotte J. Tutein Nolthenius, C. Yung Nio, Douglas A. Pendsé, Alex Menys, Cyriel Y. Ponsioen, David Atkinson, Alastair Forbes, Joachim M. Buhmann, Thomas J. Fuchs, Haralambos Hatzakis, L.J. van Vliet, Jaap Stoker, Stuart A. Taylor, F.M. Vos