Print Email Facebook Twitter Comparison between dynamic gadoxetate-enhanced MRI and 99m Tc-mebrofenin hepatobiliary scintigraphy with SPECT for quantitative assessment of liv Title Comparison between dynamic gadoxetate-enhanced MRI and 99m Tc-mebrofenin hepatobiliary scintigraphy with SPECT for quantitative assessment of liver function Author Rassam, F. (Universiteit van Amsterdam) Zhang, T. (TU Delft ImPhys/Quantitative Imaging) Cieslak, K. P. (Universiteit van Amsterdam) Lavini, C. (Universiteit van Amsterdam) Stoker, J. (Universiteit van Amsterdam) Bennink, R. J. (Universiteit van Amsterdam) van Gulik, T. M. (Universiteit van Amsterdam) van Vliet, L.J. (TU Delft ImPhys/Quantitative Imaging; TU Delft Applied Sciences) Runge, J. H. (Universiteit van Amsterdam) Vos, F.M. (TU Delft ImPhys/Quantitative Imaging; Universiteit van Amsterdam) Faculty Applied Sciences Date 2019 Abstract Objectives: To compare Gd-EOB-DTPA dynamic hepatocyte-specific contrast-enhanced MRI (DHCE-MRI) with 99m Tc-mebrofenin hepatobiliary scintigraphy (HBS) as quantitative liver function tests for the preoperative assessment of patients undergoing liver resection. Methods: Patients undergoing liver surgery and preoperative assessment of future remnant liver (FRL) function using 99m Tc-mebrofenin HBS were included. Patients underwent DHCE-MRI. Total liver uptake function was calculated for both modalities: mebrofenin uptake rate (MUR) and Ki respectively. The FRL was delineated with both SPECT-CT and MRI to calculate the functional share. Blood samples were taken to assess biochemical liver parameters. Results: A total of 20 patients were included. The HBS-derived MUR and the DHCE-MRI-derived mean Ki correlated strongly for both total and FRL function (Pearson r = 0.70, p = 0.001 and r = 0.89, p < 0.001 respectively). There was a strong agreement between the functional share determined with both modalities (ICC = 0.944, 95% CI 0.863–0.978, n = 20). There was a significant negative correlation between liver aminotransferases and bilirubin for both MUR and Ki. Conclusions: Assessment of liver function with DHCE-MRI is comparable with that of 99m Tc-mebrofenin HBS and has the potential to be combined with diagnostic MRI imaging. This can therefore provide a one-stop-shop modality for the preoperative assessment of patients undergoing liver surgery. Key Points: • Quantitative assessment of liver function using hepatobiliary scintigraphy is performed in the preoperative assessment of patients undergoing liver surgery in order to prevent posthepatectomy liver failure. • Gd-EOB-DTPA dynamic hepatocyte-specific contrast-enhanced MRI (DHCE-MRI) is an emerging method to quantify liver function and can serve as a potential alternative to hepatobiliary scintigraphy. • Assessment of liver function with dynamic gadoxetate-enhanced MRI is comparable with that of hepatobiliary scintigraphy and has the potential to be combined with diagnostic MRI imaging. Subject Gadolinium ethoxybenzyl DTPALiver function testsMagnetic resonance imagingTechnetium Tc 99m mebrofenin To reference this document use: http://resolver.tudelft.nl/uuid:1a267070-4a30-469a-99cf-c045d94198a3 DOI https://doi.org/10.1007/s00330-019-06029-7 ISSN 0938-7994 Source European Radiology, 29 (9), 5063-5072 Part of collection Institutional Repository Document type journal article Rights © 2019 F. Rassam, T. Zhang, K. P. Cieslak, C. Lavini, J. Stoker, R. J. Bennink, T. M. van Gulik, L.J. van Vliet, J. H. Runge, F.M. Vos Files PDF Rassam2019_Article_Compar ... Gadoxe.pdf 6.85 MB Close viewer /islandora/object/uuid:1a267070-4a30-469a-99cf-c045d94198a3/datastream/OBJ/view