Choline chloride-based des as solvents/catalysts/chemical donors in pharmaceutical synthesis

Title

Choline chloride-based des as solvents/catalysts/chemical donors in pharmaceutical synthesis

 Author

Amoroso, Rosa (University G. D'Annunzio of Chieti-Pescara)
Hollmann, F. (TU Delft BT/Biocatalysis) ORCID 0000-0003-4821-756X
Maccallini, Cristina (University G. D'Annunzio of Chieti-Pescara)

Date

2021

 Abstract

DES are mixtures of two or more compounds, able to form liquids upon mixing, with lower freezing points when compared to the individual constituents (eutectic mixtures). This attitude is due to the specific hydrogen-bond interactions network between the components of the mixture. A notable characteristic of DES is the possibility to develop tailor-made mixtures by changing the components ratios or a limited water dilution, for special applications, making them attractive for pharmaceutical purposes. In this review, we focused our attention on application of ChCl-based DES in the synthesis of pharmaceutical compounds. In this context, these eutectic mixtures can be used as solvents, solvents/catalysts, or as chemical donors and we explored some representative examples in recent literature of such applications.


 Subject

Catalyst
Choline chloride
NADES
Pharmaceuticals
Solvent

 To reference this document use:

http://resolver.tudelft.nl/uuid:268b314a-6d04-4465-b158-246b5768a076

 DOI

https://doi.org/10.3390/molecules26206286

 ISSN

1420-3049

 Source

Molecules: a journal of synthetic organic and natural product chemistry, 26 (20)

 Part of collection

Institutional Repository

 Document type

review

 Rights

© 2021 Rosa Amoroso, F. Hollmann, Cristina Maccallini
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