Print Email Facebook Twitter Towards photon radiotherapy treatment planning with high Z nanoparticle radiosensitisation agents Title Towards photon radiotherapy treatment planning with high Z nanoparticle radiosensitisation agents: The Relative Biological Effective Dose (RBED) framework Author Brown, J.M.C. (TU Delft RST/Medical Physics & Technology; Queen's University Belfast; University of Wollongong) Hanna, Gerard G. (Queen's University Belfast) Lampe, Nathanael (Université d'Auvergne) Villagomez-Bernabe, Balder (Queen's University Belfast) Nicol, James R. (Queen's University Belfast) Coulter, Jonathan A. (Queen's University Belfast) Currell, Fred J. (Queen's University Belfast) Date 2018 Abstract A novel treatment planning framework, the Relative Biological Effective Dose (RBED), for high Z nanoparticle (NP)-enhanced photon radiotherapy is developed and tested in silico for the medical exemplar of neoadjuvant (preoperative) breast cancer MV photon radiotherapy. Two different treatment scenarios, conventional and high Z NP enhanced, were explored with a custom Geant4 application that was developed to emulate the administration of a single 2 Gy fraction as part of a 50 Gy radiotherapy treatment plan. It was illustrated that there was less than a 1% difference in the dose deposition throughout the standard and high Z NP-doped adult female phantom. Application of the RBED framework found that the extent of possible biological response with high Z NP doping was great than expected via the dose deposition alone. It is anticipated that this framework will assist the scientific community in future high Z NP-enhanced in-silico, pre-clinical and clinical trials. Subject Biological effect modellingNanoparticlesRadiosensitisersRadiotherapyTheranostic nanoparticlesTreatment planning To reference this document use: http://resolver.tudelft.nl/uuid:443a96b5-2225-454c-beaf-2acbfacc38d3 DOI https://doi.org/10.1186/s12645-018-0043-7 ISSN 1868-6958 Source Cancer Nanotechnology, 9 (1) Part of collection Institutional Repository Document type journal article Rights © 2018 J.M.C. Brown, Gerard G. Hanna, Nathanael Lampe, Balder Villagomez-Bernabe, James R. Nicol, Jonathan A. Coulter, Fred J. Currell Files PDF s12645_018_0043_7.pdf 2.62 MB Close viewer /islandora/object/uuid:443a96b5-2225-454c-beaf-2acbfacc38d3/datastream/OBJ/view