Print Email Facebook Twitter Influence of laser parameters and experimental conditions on nonphotochemical laser-induced nucleation of glycine polymorphs Title Influence of laser parameters and experimental conditions on nonphotochemical laser-induced nucleation of glycine polymorphs Author Irimia, D. (TU Delft Intensified Reaction and Separation Systems; TU Delft Complex Fluid Processing) Jose Shirley, J. (TU Delft ChemE/Delft Ingenious Design) Garg, Anshul S. (Student TU Delft) Nijland, Davey P.A. (Student TU Delft) van der Heijden, A.E.D.M. (TU Delft Complex Fluid Processing; TU Delft Intensified Reaction and Separation Systems) Kramer, H.J.M. (TU Delft Intensified Reaction and Separation Systems; TU Delft Complex Fluid Processing) Eral, H.B. (TU Delft Intensified Reaction and Separation Systems; TU Delft Complex Fluid Processing) Date 2021 Abstract Nonphotochemical laser-induced nucleation (NPLIN) is a promising primary nucleation control method, yet its underlying mechanism remains elusive. To contribute to the discussion on whether the polarization of laser irradiation in NPLIN experiments influences the polymorphic outcome, we revisit NPLIN experiments with aqueous glycine solutions with supersaturations ranging between S = 1.5 and S = 1.7 irradiated by nanosecond pulses (∼7 ns) of near-infrared wavelength (1064 nm). Systematically altering laser light excitation properties, including the number of pulses and type of polarization, we quantified the nucleation kinetics and characterized the polymorphic form that crystallized upon laser irradiation. Due to the stochasticity of the nucleation process, a large number of samples (>100 per each experimental point) were studied under carefully controlled experimental conditions such as the ambient temperature, cooling rate, and aging period. We observed significant differences among laser-irradiated, spontaneously nucleated, and crash-cooled samples in terms of nucleation kinetics and polymorphic form. This result indicates that laser irradiation provides a different polymorph-forming pathway in comparison to crash-cooling and spontaneous nucleation. However, no clear dependence between the polymorphic form and the polarization of laser irradiation is observed. We discuss our results in the context of previous reports supported thorough quantification of sample heating in NPLIN experiments. To reference this document use: http://resolver.tudelft.nl/uuid:57aaab4b-d55a-4d44-8619-198078dc540c DOI https://doi.org/10.1021/acs.cgd.0c01415 Embargo date 2021-06-22 ISSN 1528-7483 Source Crystal Growth & Design, 21 (1), 631−641 Bibliographical note Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public. Part of collection Institutional Repository Document type journal article Rights © 2021 D. Irimia, J. Jose Shirley, Anshul S. Garg, Davey P.A. Nijland, A.E.D.M. van der Heijden, H.J.M. Kramer, H.B. Eral Files PDF acs.cgd.0c01415.pdf 4.21 MB Close viewer /islandora/object/uuid:57aaab4b-d55a-4d44-8619-198078dc540c/datastream/OBJ/view