Print Email Facebook Twitter Computational 3D resolution enhancement for optical coherence tomography with a narrowband visible light source Title Computational 3D resolution enhancement for optical coherence tomography with a narrowband visible light source Author de Wit, J. (TU Delft ImPhys/Computational Imaging; TU Delft ImPhys/Kalkman group) Glentis, George Othon (University of Peloponnese) Kalkman, J. (TU Delft ImPhys/Computational Imaging; TU Delft ImPhys/Kalkman group) Date 2023 Abstract Phase-preserving spectral estimation optical coherence tomography (SE-OCT) enables combining axial resolution improvement with computational depth of field (DOF) extension. We show that the combination of SE-OCT with interferometric synthetic aperture microscopy (ISAM) and computational adaptive optics (CAO) results in high 3D resolution over a large depth range for an OCT system with a narrow bandwidth visible light super-luminescent diode (SLD). SE-OCT results in up to five times axial resolution improvement from 8 µm to 1.5 µm. The combination with ISAM gives a sub-micron lateral resolution over a 400 µm axial range, which is at least 16 times the conventional depth of field. CAO can be successfully applied after SE and ISAM and removes residual aberrations, resulting in high quality images. The results show that phase-preserving SE-OCT is sufficiently accurate for coherent post-processing, enabling the use of cost-effective SLDs in the visible light range for high spatial resolution OCT. Subject OA-Fund TU Delft To reference this document use: http://resolver.tudelft.nl/uuid:5f560168-76b9-4715-bc3a-08a40b44a0c1 DOI https://doi.org/10.1364/BOE.487345 ISSN 2156-7085 Source Biomedical Optics Express, 14 (7), 3532-3554 Part of collection Institutional Repository Document type journal article Rights © 2023 J. de Wit, George Othon Glentis, J. Kalkman Files PDF 1_s2.0_S1470204523002863_main.pdf 944.03 KB Close viewer /islandora/object/uuid:5f560168-76b9-4715-bc3a-08a40b44a0c1/datastream/OBJ/view