Print Email Facebook Twitter Chemoenzymatic intermolecular haloether synthesis Title Chemoenzymatic intermolecular haloether synthesis Author Chen, Shaohang (Wuhan University of Science and Technology) Zhang, Jiaan (Wuhan University of Science and Technology) Zeng, Zhigang (Wuhan University of Science and Technology) Dai, Zongjie (Chinese Academy of Sciences) Wang, Qinhong (Chinese Academy of Sciences) Wever, Ron (Universiteit van Amsterdam) Hollmann, F. (TU Delft BT/Biocatalysis) Zhang, W. (TU Delft BT/Biocatalysis; Chinese Academy of Sciences) Date 2022 Abstract A chemoenzymatic method for the synthesis of haloethers is presented. A combination of enzymatic hypohalite synthesis with spontaneous oxidation of alkenes and nucleophilic attack by various alcohols enabled the synthesis of a wide range of haloethers. The reaction system has been characterised and current imitations have been worked out. In the present, aqueous reaction system, hydroxyhalide formation represents the main undesired side reaction. Nevertheless, semi-preparative scale synthesis of a range of haloethers is demonstrated. Subject Chemoenzymatic synthesisEther synthesisHaloetherificationVanadium chloroperoxidase To reference this document use: http://resolver.tudelft.nl/uuid:69f97604-bdda-466f-8482-91a0884fcfff DOI https://doi.org/10.1016/j.mcat.2021.112061 ISSN 2468-8231 Source Molecular Catalysis, 517 Part of collection Institutional Repository Document type journal article Rights © 2022 Shaohang Chen, Jiaan Zhang, Zhigang Zeng, Zongjie Dai, Qinhong Wang, Ron Wever, F. Hollmann, W. Zhang Files PDF 1_s2.0_S2468823121006775_main.pdf 1.09 MB Close viewer /islandora/object/uuid:69f97604-bdda-466f-8482-91a0884fcfff/datastream/OBJ/view