Print Email Facebook Twitter On the Michael Addition of Water to ?,?-Unsaturated Ketones Using Amino Acids Title On the Michael Addition of Water to ?,?-Unsaturated Ketones Using Amino Acids Author Resch, V. Seidler, C. Chen, B.S. Degeling, I. Hanefeld, U. Faculty Applied Sciences Department BT/Biotechnology Date 2013-10-15 Abstract The use of water as a nucleophile for Michael additions is still a challenge in organic chemistry. In this report we describe the use of amino acids as catalysts for the Michael addition of water to ?,?-unsaturated ketones. All 20 proteinogenic amino acids were screened and L-lysine was identified as the best candidate. To obtain a better insight and to determine the minimum requirements of the catalyst, several structurally related compounds were tested. The reaction was characterized in terms of conditions and equilibrium. Subject organocatalysisamino acidswater chemistrygreen chemistryMichael addition To reference this document use: http://resolver.tudelft.nl/uuid:7f8c4181-6a32-4a7c-82c5-de80d77a7f23 DOI https://doi.org/10.1002/ejoc.201301230 Publisher Wiley ISSN 1434-193X Source European Journal of Organic Chemistry, (34), 2013 Part of collection Institutional Repository Document type journal article Rights © 2013 The Author(s)This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Files PDF Resch_2013.pdf 645.57 KB Close viewer /islandora/object/uuid:7f8c4181-6a32-4a7c-82c5-de80d77a7f23/datastream/OBJ/view