Print Email Facebook Twitter Chemical signal regulated injectable coacervate hydrogels Title Chemical signal regulated injectable coacervate hydrogels Author Wu, B. (TU Delft ChemE/Advanced Soft Matter; East China University of Science and Technology) Lewis, R.W. (TU Delft ChemE/Advanced Soft Matter) Li, G. (TU Delft ChemE/Advanced Soft Matter) Gao, Yifan (East China University of Science and Technology) Fan, B. (TU Delft ChemE/Advanced Soft Matter) Klemm, B. (TU Delft ChemE/Advanced Soft Matter) Huang, J. (East China University of Science and Technology) Wang, Junyou (East China University of Science and Technology) Cohen Stuart, Martien A. (East China University of Science and Technology) Eelkema, R. (TU Delft ChemE/Advanced Soft Matter) Date 2023 Abstract In the quest for stimuli-responsive materials with specific, controllable functions, coacervate hydrogels have become a promising candidate, featuring sensitive responsiveness to environmental signals enabling control over sol-gel transitions. However, conventional coacervation-based materials are regulated by relatively non-specific signals, such as temperature, pH or salt concentration, which limits their possible applications. In this work, we constructed a coacervate hydrogel with a Michael addition-based chemical reaction network (CRN) as a platform, where the state of coacervate materials can be easily tuned by specific chemical signals. We designed a pyridine-based ABA triblock copolymer, whose quaternization can be regulated by an allyl acetate electrophile and an amine nucleophile, leading to gel construction and collapse in the presence of polyanions. Our coacervate gels showed not only highly tunable stiffness and gelation times, but excellent self-healing ability and injectability with different sized needles, and accelerated degradation resulting from chemical signal-induced coacervation disruption. This work is expected to be a first step in the realization of a new class of signal-responsive injectable materials. To reference this document use: http://resolver.tudelft.nl/uuid:7fd7a2af-2eb1-4589-8a51-f02805183146 DOI https://doi.org/10.1039/d2sc06935k ISSN 2041-6520 Source Chemical Science, 14 (6), 1512-1523 Part of collection Institutional Repository Document type journal article Rights © 2023 B. Wu, R.W. Lewis, G. Li, Yifan Gao, B. Fan, B. Klemm, J. Huang, Junyou Wang, Martien A. Cohen Stuart, R. Eelkema Files PDF d2sc06935k.pdf 1.67 MB Close viewer /islandora/object/uuid:7fd7a2af-2eb1-4589-8a51-f02805183146/datastream/OBJ/view