Print Email Facebook Twitter Nonlinearity-modulated single molecule trapping and Raman scattering analysis Title Nonlinearity-modulated single molecule trapping and Raman scattering analysis Author Zhang, Shuoshuo (Shenzhen University) Zhang, Yuquan (Shenzhen University) Fu, Yanan (Shenzhen University) Zhu, Z. (TU Delft ImPhys/Optics; Shenzhen University) Man, Zhongsheng (Shandong University of Technology; Shandong Normal University) Bu, Jing (Shenzhen University) Fang, Hui (Shenzhen University) Min, Changjun (Shenzhen University) Yuan, Xiaocong (Shenzhen University) Date 2021 Abstract Single molecule detection and analysis play important roles in many current biomedical researches. The deep-nanoscale hotspots, being excited and confined in a plasmonic nanocavity, make it possible to simultaneously enhance the nonlinear light-matter interactions and molecular Raman scattering for label-free detections. Here, we theoretically show that a nanocavity formed in a tip-enhanced Raman scattering (TERS) system can also achieve valid optical trapping as well as TERS signal detection for a single molecule. In addition, the nonlinear responses of metallic tip and substrate film can change their intrinsic physical properties, leading to the modulation of the optical trapping force and the TERS signal. The results demonstrate a new degree of freedom brought by the nonlinearity for effectively modulating the optical trapping and Raman detection in single molecule level. This proposed platform also shows a great potential in various fields of research that need high-precision surface imaging. To reference this document use: http://resolver.tudelft.nl/uuid:9d9ff795-5300-4f67-9e38-856be956f065 DOI https://doi.org/10.1364/OE.437647 ISSN 1094-4087 Source Optics Express, 29 (20), 32285-32295 Part of collection Institutional Repository Document type journal article Rights © 2021 Shuoshuo Zhang, Yuquan Zhang, Yanan Fu, Z. Zhu, Zhongsheng Man, Jing Bu, Hui Fang, Changjun Min, Xiaocong Yuan Files PDF oe_29_20_32285.pdf 5.23 MB Close viewer /islandora/object/uuid:9d9ff795-5300-4f67-9e38-856be956f065/datastream/OBJ/view