FET-based integrated charge sensor for organ-on-chip applications

FET-based integrated charge sensor for organ-on-chip applications

Aydogmus, H. (TU Delft Electronic Components, Technology and Materials)
Dostanic, M. (TU Delft Electronic Components, Technology and Materials)
Jahangiri, M. (TU Delft Electronic Instrumentation)
Sinha, Rajarshi
Quiros Solano, W.F. (TU Delft Electronic Components, Technology and Materials)
Mastrangeli, Massimo (TU Delft Electronic Components, Technology and Materials)
Sarro, Pasqualina M (TU Delft Electronic Components, Technology and Materials)

2020

We present an extremely compact field effect transistor (FET)-based electrochemical sensor for in situ real-time and label-free measurement of ion concentrations in the cell culture area of organs-on-chip (OoCs) devices. This sensor replaces the functionality of an external reference electrode, crucial in standard electrochemical sensing, by controlling the FET threshold voltage via a capacitive control gate. The silicon- and polymer-based charge sensor can be integrated in OoC platforms by means of a wafer-scale and CMOS-compatible microfabrication process. This fabrication approach inherently allows a superior level of accuracy, repeatability and scalability compared to common OoC manufacturing methods. The sensor combines in a single device the complementary benefits of silicon-based electronics and of flexible polymer membranes with integrated microelectrodes – congenial substrates to sustain dynamic stimuli and mimic physiological tissue microenvironments. The integration of the polymer membrane in the sensing region makes this miniature sensor a preferable option for high sensitivity biochemical measurements in OoC applications, including monitoring the pH of cell culture media and of tissue culturing microenvironments, quantification of ion displacement in cells, and complementary research on disease modeling.

http://resolver.tudelft.nl/uuid:9f1b3ed8-e287-44ef-afdd-baea6dbb7e80

https://doi.org/10.1109/SENSORS47125.2020.9278692

2021-12-06

:978-1-7281-6801-2

IEEE Sensors, SENSORS 2020 - Conference Proceedings

Proceedings of IEEE Sensors, 1930-0395, 2020-October

Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.

Institutional Repository

conference paper

© 2020 H. Aydogmus, M. Dostanic, M. Jahangiri, Rajarshi Sinha, W.F. Quiros Solano, Massimo Mastrangeli, Pasqualina M Sarro