Print Email Facebook Twitter Selective Peroxygenase-Catalysed Oxidation of Toluene Derivates to Benzaldehydes Title Selective Peroxygenase-Catalysed Oxidation of Toluene Derivates to Benzaldehydes Author Wang, Y. (TU Delft BT/Biocatalysis; Tianjin University) Teetz, Niklas (University of Applied Sciences Mittelhessen) Holtmann, Dirk (University of Applied Sciences Mittelhessen) Alcalde, Miguel (Institute of Catalysis, CSIC, Madrid) van Hengst, J.M.A. (TU Delft BT/Biocatalysis) Liu, Xiaoxiao (Chinese Academy of Sciences) Wang, Mengfan (Tianjin University) Qi, Wei (Tianjin University) Zhang, Wuyuan (Chinese Academy of Sciences) Hollmann, F. (TU Delft BT/Biocatalysis) Date 2023 Abstract Biocatalytic oxidation reactions of toluene derivates to the corresponding aldehydes are typically challenged by regio- and chemoselectivity issues. In this contribution we address both challenges by a combined reactant- and reaction engineering approach. We demonstrate that the peroxygenase-catalysed transformation of ring-substituted toluenes proceeds highly regioselectively in benzylic position. Furthermore, neat reaction conditions not only enable attractive product concentrations (up to 185 mM) but also result in highly chemoselective oxidations to the aldehyde level. Subject BenzaldehydesBiocatalytic oxidationPeroxygenaseSelective oxyfunctionalisationSolvent-free biocatalysis To reference this document use: http://resolver.tudelft.nl/uuid:ab9002c8-475b-43a9-9455-b92727e8f965 DOI https://doi.org/10.1002/cctc.202300645 ISSN 1867-3880 Source ChemCatChem, 15 (13) Part of collection Institutional Repository Document type journal article Rights © 2023 Y. Wang, Niklas Teetz, Dirk Holtmann, Miguel Alcalde, J.M.A. van Hengst, Xiaoxiao Liu, Mengfan Wang, Wei Qi, Wuyuan Zhang, F. Hollmann Files PDF ChemCatChem_2023_Wang_Sel ... ehydes.pdf 2.27 MB Close viewer /islandora/object/uuid:ab9002c8-475b-43a9-9455-b92727e8f965/datastream/OBJ/view