Print Email Facebook Twitter The study of calcium oxalate kidney stone growth in microfluidic channel Title The study of calcium oxalate kidney stone growth in microfluidic channel Author Wang, Jiali (TU Delft Applied Sciences) Contributor Ibis, F. (mentor) Eral, H.B. (mentor) Degree granting institution Delft University of Technology Programme Applied Physics Project Kidney stone project Date 2020-08-18 Abstract Kidney stone disease influences 10% of people in the world [36]. Calcium oxalate (CaOx) stones are the most common stones found in the kidney stone. In this research, ANSYS/Fluent CFD was used to determine the supersaturation profile in the microchannel for different constant flow rates and Ca and Ox inlet concentrations. The growth of the CaOx stones is studied by performing experiments in a microfluidic channel under an optical microscopy. The growth of the CaOx stones is also investigated by using a combined transport-kinetics model which couple both mass transport and CaOx precipitationreaction at the surface of the crystal. It is shown that the crystal growth rate increases with solution supersaturation increasing and decreases with the crystal size increasing. The findings also indicated that in cases of low bulk solution supersaturation and low surface reaction constant values,the crystal growth rates are controlled by the surface reaction kinetics and independent on the species transport. When the bulk solution supersaturation and surface reaction constant values are high, the Ca and Ox surface concentrations become lower than the bulk solution concentration values. Thus,the crystal growth rates are controlled by the species transport. The presented study also shows that in the presence of inhibitor osteopontin, the crystal growth rate was decreased. Subject kidney stones To reference this document use: http://resolver.tudelft.nl/uuid:c3a23e3e-c4c9-47a4-9472-0e35fac77c5c Embargo date 2023-01-03 Part of collection Student theses Document type master thesis Rights © 2020 Jiali Wang Files PDF Thesis_report_Jiali_Wang.pdf 13.64 MB Close viewer /islandora/object/uuid:c3a23e3e-c4c9-47a4-9472-0e35fac77c5c/datastream/OBJ/view