Print Email Facebook Twitter A calibrated physical flow standard for medical perfusion imaging Title A calibrated physical flow standard for medical perfusion imaging Author Kok, G. (VSL Dutch Metrology Institute) Pelevic, N. (VSL Dutch Metrology Institute) Chiribiri, A. (King’s College London) Milidonis, X. (King’s College London) Nazir, M. (King’s College London) Capstick, M. (Zurich MedTech AG, Zurich) Drost, S. Poelma, C. (TU Delft Multi Phase Systems) Schaeffter, T. (Physikalisch-Technische Bundesanstalt) Date 2021 Abstract In the medical sector, various imaging methodologies or modalities (e.g. MRI, PET, CT) are used to assess the health of various parts of the bodies of patients. One such investigation is the blood flow or perfusion of the heart muscle, expressed as the (blood) flow rate normalized by the mass of the volume of interest. Currently there is no physical flow standard for the validation of quantitative perfusion measurements. This need has been addressed in the EMPIR 15HLT05 PerfusImaging project. A phantom simulating the heart muscle has been developed with the capability that it can reproducibly generate a flow profile with individual flow rates known with a relative uncertainty of about 10% (k = 2) and total flow rate known with an uncertainty of 1% (k = 2). An overview of the phantom and its validation is given. Next, a new analysis method is presented to analyse the sequence of images which are acquired when using a standard dynamic imaging protocol. It is concluded that the new, alternative approach gives results comparable to the standard analysis method. Subject CalibrationCFDModellingMRIPerfusionUIV To reference this document use: http://resolver.tudelft.nl/uuid:cfe63e61-212a-4ac1-b964-6a6f0e762e51 DOI https://doi.org/10.1016/j.flowmeasinst.2021.101907 ISSN 0955-5986 Source Flow Measurement and Instrumentation, 78 Part of collection Institutional Repository Document type journal article Rights © 2021 G. Kok, N. Pelevic, A. Chiribiri, X. Milidonis, M. Nazir, M. Capstick, S. Drost, C. Poelma, T. Schaeffter Files PDF 1_s2.0_S0955598621000224_main.pdf 4.04 MB Close viewer /islandora/object/uuid:cfe63e61-212a-4ac1-b964-6a6f0e762e51/datastream/OBJ/view