Print Email Facebook Twitter Model prediction of subendocardial perfusion of the coronary circulation in the presence of an epicardial coronary artery stenosis Title Model prediction of subendocardial perfusion of the coronary circulation in the presence of an epicardial coronary artery stenosis Author Van den Wijngaard, J.P.H.M. Kolyva, C. Siebes, M. Dankelman, J. Van Gemert, M.J.C. Piek, J.J. Spaan, J.A.E. Faculty Applied Sciences Department Department of BioMechanical Engineering Date 2008-02-14 Abstract The subendocardium is most vulnerable to ischemia, which is ameliorated by relaxation during diastole and increased coronary pressure. Recent clinical techniques permit the measuring of subendocardial perfusion and it is therefore important to gain insight into how measurements depend on perfusion conditions of the heart. Using data from microsphere experiments a layered model of the myocardial wall was developed. Myocardial perfusion distribution during hyperemia was predicted for different degrees of coronary stenosis and at different levels of Diastolic Time Fraction (DTF). At the reference DTF, perfusion was rather evenly distributed over the layers and the effect of the stenosis was homogenous. However, at shorter or longer DTF, the subendocardium was the first or last to suffer from shortage of perfusion. It is therefore concluded that the possible occurrence of subendocardial ischemia at exercise is underestimated when heart rate is increased and DTF is lower. Subject Coronary reserveStealHeart modelRegional conductanceDiastolic time fraction To reference this document use: http://resolver.tudelft.nl/uuid:e3b442bb-5cda-4dbb-b2ef-f0d8eef4f543 Publisher Springer ISSN 1741-0444 Source Medical and Biological Engineering and Computing, 46 (5) Part of collection Institutional Repository Document type journal article Rights (c) 2008 The Authors Files PDF wijngaard_2008.pdf 413.29 KB Close viewer /islandora/object/uuid:e3b442bb-5cda-4dbb-b2ef-f0d8eef4f543/datastream/OBJ/view