Incorporation of Contracture Formation during Dermal Wound Healing: A Mathematical Model

In order to rapidly close skin wounds and prevent further infection, the process of contraction is initiated during wound healing. However, this process has the potential to become problematic as it may result in permanent contraction, or contracture formation. In order to give an insight in the dynamics involved with this process, we present a mathematical model of dermal wound healing which incorporates the contraction process and the possibility to develop a contracture as a consequence of wound healing. We consider various prominent mediators in the wound healing process and model the influences that each of these mediators has on each other and their surroundings. Using the model, we find that the number of myofibroblasts and the forces they exert on their surroundings are important factors in the degree of contracture formation.

Subject

contraction
myofibroblasts
transforming growth factor-b
collagen synthesis

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Student theses

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master thesis

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