Distant non-obvious mutations influence the activity of a hyperthermophilic Pyrococcus furiosus phosphoglucose isomerase

The cupin-type phosphoglucose isomerase (PfPGI) from the hyperthermophilic archaeon Pyrococcus furiosus catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate. We investigated PfPGI using protein-engineering bioinformatics tools to select functionally-important residues based on correlated mutation analyses. A...

Material model for non-linear finite element analyses of large concrete structures

A fully triaxial material model for concrete was implemented in a commercial finite element code. The only required input parameter was the cylinder compressive strength. The material model was suitable for non-linear finite element analyses of large concrete structures. The importance of including a crack closure algorithm was demonstrated on a...

A tool for concrete performance assessment for ASR affected structures: An outlook

This paper outlines a project (namely PAT-ASR) which entails the development of a multi scale material performance assessment model on simulation of alkali silica reaction deployment and its effects on concrete durability. Performance models require a multi scale approach from micro (namely reaction chemistry) to macro level studies (namely...

Adaptability in deep water infrastructure installation